{"id":"W2317924448","doi":"10.5414/cp201546","title":"Safety, tolerability, and pharmacokinetics of once-daily trazodone extended-release caplets in healthy subjects","year":2011,"lang":"en","type":"article","venue":"International Journal of Clinical Pharmacology and Therapeutics","topic":"Treatment of Major Depression","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Pharmacokinetics; Trazodone; Tolerability; Bioavailability; Ingestion; Oral administration; Pharmacology; Area under the curve; Medicine; Meal; Internal medicine; Adverse effect; Antidepressant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006755386,0.0004881083,0.0006543947,0.0002178464,0.0002616417,0.0003591784,0.0001900915,0.0005174448,0.001078848],"category_scores_gemma":[0.0008667223,0.0002005292,0.0002465255,0.0001707625,0.00029531,0.0002382737,0.00009221856,0.0004793244,0.000360014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002437164,"about_ca_system_score_gemma":0.0002502495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100436,"about_ca_topic_score_gemma":0.0008498524,"domain_scores_codex":[0.9996688,0.0001204371,0.00002051675,0.00007676019,0.00008673336,0.00002677246],"domain_scores_gemma":[0.9995018,0.0001351183,0.0001570217,0.00003982346,0.00007230425,0.00009383164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1973843,0.01906147,0.1831023,0.001511707,0.0009060007,0.00302108,0.001176,0.001224802,0.3759714,0.0001517595,0.001847216,0.214642],"study_design_scores_gemma":[0.00543442,0.3092979,0.6541745,0.00006308665,0.0005500456,0.003081058,0.0002803477,0.002508977,0.02164662,0.00005919483,0.002840134,0.00006368005],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974366,0.001402599,0.0003241506,0.00001985285,0.00001209338,0.0001294063,0.0001982157,0.00002741164,0.0004496889],"genre_scores_gemma":[0.9978314,0.0005912436,0.00048349,0.0001020354,0.00003630233,0.00008916786,0.0003277034,0.000006898258,0.0005316732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100436,"threshold_uncertainty_score":0.003609121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1057151139971319,"score_gpt":0.4513624411461794,"score_spread":0.3456473271490474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}