{"id":"W2317927804","doi":"10.1042/bj20112119","title":"Force-induced apoptosis mediated by the Rac/Pak/p38 signalling pathway is regulated by filamin A","year":2012,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Yale University; Heart and Stroke Foundation of Canada","keywords":"Filamin; Cell biology; Apoptosis; p38 mitogen-activated protein kinases; Effector; HEK 293 cells; PAK1; Chemistry; Kinase; Protein kinase A; Biology; Cell; Receptor; Cytoskeleton; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000370716,0.000226278,0.0001685353,0.00003167251,0.0002401515,0.00008315747,0.0003325557,0.0003108121,0.0003809324],"category_scores_gemma":[0.00016231,0.0001650137,0.0002257361,0.0001059541,0.00003850404,0.00001324386,0.0001055502,0.0004295708,0.00003441129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004298953,"about_ca_system_score_gemma":0.0000540853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001068966,"about_ca_topic_score_gemma":4.757111e-7,"domain_scores_codex":[0.9985203,0.00008772154,0.0003775684,0.0002489199,0.0002660917,0.0004994184],"domain_scores_gemma":[0.9990491,0.00003861243,0.0002064856,0.0002684106,0.0001321367,0.0003052295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003741683,0.00009582257,0.00001856881,0.000002506088,0.00008669144,3.651038e-7,0.0000476506,2.214648e-7,0.7884579,0.000006416116,0.2107486,0.0004978143],"study_design_scores_gemma":[0.0003895599,0.0001049157,0.000004248502,0.00001780333,0.00003143616,0.00009943734,0.00008659918,0.0001552334,0.8739535,0.00002615638,0.1249276,0.0002035393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915559,0.003985771,0.002415633,0.001077562,0.0004295553,0.0001334141,0.0001038885,0.00001409928,0.000284229],"genre_scores_gemma":[0.9958653,0.0003700159,0.0001210423,0.001103368,0.0006639425,0.00001249647,0.0004475567,0.00003808821,0.0013782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08582095,"threshold_uncertainty_score":0.6729063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161565582513646,"score_gpt":0.2365938031045587,"score_spread":0.2249781472794223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}