{"id":"W2317995771","doi":"10.1038/sj.onc.1205669","title":"ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation","year":2002,"lang":"en","type":"article","venue":"Oncogene","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; BC Research (Canada); University of British Columbia","funders":"","keywords":"Biology; PI3K/AKT/mTOR pathway; Protein kinase B; Tyrosine phosphorylation; Growth factor receptor; Receptor tyrosine kinase; Cancer research; MAPK/ERK pathway; Cell biology; Molecular biology; Growth factor; Insulin receptor; Signal transduction; Tyrosine kinase; Phosphorylation; Receptor; Endocrinology; Insulin; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006446086,0.0001486723,0.000136858,0.00003232582,0.0001240002,0.00002498401,0.0000540513,0.0001990182,0.00008867706],"category_scores_gemma":[0.00003072629,0.0001177234,0.00004225233,0.0001226513,0.0001183349,0.00001506802,0.00001159263,0.00009090322,0.00001021171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004990878,"about_ca_system_score_gemma":0.00003967271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002334213,"about_ca_topic_score_gemma":0.000012034,"domain_scores_codex":[0.9992471,0.00003563302,0.0001787013,0.0002324527,0.0001360321,0.000170122],"domain_scores_gemma":[0.9996029,0.00001343728,0.0001058025,0.00008329265,0.0001200534,0.00007447577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000203211,0.00006142967,0.0005482445,0.00002033906,0.0002351556,0.000003589294,0.0008796742,0.0001002396,0.9886807,0.00005580619,0.001368107,0.007843467],"study_design_scores_gemma":[0.001597677,0.0004859063,0.0002403296,0.00009546288,0.0000579172,0.00001288768,0.00008922879,0.0003307444,0.9866551,0.00002531164,0.01013614,0.0002732882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919892,0.00378685,0.0009719526,0.000299032,0.0001250922,0.0001957413,0.0001079821,0.00002223087,0.002501907],"genre_scores_gemma":[0.9957396,0.002998934,0.0001756772,0.0003176634,0.00007488389,0.00001083944,0.0002002835,0.00001503493,0.0004670934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008768032,"threshold_uncertainty_score":0.4800622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216009624355806,"score_gpt":0.2120984596500542,"score_spread":0.1999383634064961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}