{"id":"W2318023690","doi":"10.1021/jo0158229","title":"Synthesis of Boroxifen, A <i>N</i><i>ido-</i>Carborane Analogue of Tamoxifen","year":2001,"lang":"he","type":"article","venue":"The Journal of Organic Chemistry","topic":"Boron Compounds in Chemistry","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Carborane; Tamoxifen; Chemistry; Prodrug; Boron; Acetonitrile; Antiestrogen; Decaborane; Stereochemistry; Nuclear magnetic resonance spectroscopy; Combinatorial chemistry; Organic chemistry; Breast cancer; Cancer; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002390143,0.0005727362,0.001836649,0.00008029381,0.00009503641,0.00001692959,0.001659486,0.0005523182,0.006114356],"category_scores_gemma":[0.002424163,0.0004342486,0.0006108198,0.0009439589,0.000748518,0.0001173401,0.0002886605,0.001527678,0.00001841743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003615135,"about_ca_system_score_gemma":0.001462159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003773001,"about_ca_topic_score_gemma":0.00000594717,"domain_scores_codex":[0.9948009,0.0001877943,0.002614954,0.0003034609,0.001475349,0.0006175258],"domain_scores_gemma":[0.9916615,0.001630189,0.003519823,0.001561431,0.001202791,0.0004242973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001316851,0.0007714262,0.00404233,0.00199799,0.001278786,0.0002598192,0.0005949004,0.00001254787,0.984499,0.000002271741,0.004655568,0.0005685008],"study_design_scores_gemma":[0.002195159,0.0002115604,0.0008583219,0.002693538,0.00293776,0.005559171,0.001568325,0.00003078394,0.9813291,0.0001182714,0.00217619,0.0003218646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746764,0.01207127,0.000104775,0.002941575,0.0005553959,0.0001693357,0.0001022564,0.00001906183,0.009359948],"genre_scores_gemma":[0.9882444,0.008317366,0.0002547743,0.0001336454,0.00163966,0.000001388752,0.000005615651,0.0001094898,0.001293716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01356797,"threshold_uncertainty_score":0.9998109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216966486950367,"score_gpt":0.2462112571292117,"score_spread":0.2340415922597081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}