{"id":"W2318040934","doi":"10.1021/ml500260j","title":"Conjugation and Evaluation of Small Hydrophobic Molecules to Triazole-Linked siRNAs","year":2014,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Small interfering RNA; Gene silencing; RNA interference; Chemistry; Luciferase; Cell biology; RNA; Transfection; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005042689,0.0001314366,0.0001508249,0.0000260011,0.00003034329,0.000009230694,0.0001390712,0.00009418578,0.00001770209],"category_scores_gemma":[0.0001912432,0.0001260102,0.00003881182,0.00005742933,0.00008442148,0.00000295306,0.00004989571,0.00007065674,0.000004052974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001592401,"about_ca_system_score_gemma":0.00003863719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002180491,"about_ca_topic_score_gemma":0.000004252161,"domain_scores_codex":[0.9990299,0.00005867796,0.0002253533,0.000281071,0.0002565168,0.0001485266],"domain_scores_gemma":[0.999384,0.0000200884,0.000102378,0.0002448595,0.0001567773,0.00009193974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009133133,0.00001371385,0.0002939717,0.00003675607,0.00003047996,7.391703e-7,0.00007166182,0.0002484093,0.9943255,0.000002006766,0.0007282295,0.004157233],"study_design_scores_gemma":[0.0009641669,0.0001366815,0.001284113,0.00005340414,0.00008196588,0.00001396844,0.00008540493,0.0008478374,0.9955477,0.00003326271,0.0008101524,0.0001413089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964505,0.0001973338,0.001506493,0.001005032,0.00007006605,0.0001441771,0.000003798648,0.000005966131,0.0006166147],"genre_scores_gemma":[0.9978256,0.00003238248,0.0002066215,0.001496525,0.000268514,0.0000201744,0.00009768612,0.00001123604,0.00004121397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004015924,"threshold_uncertainty_score":0.5138545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01812003434700045,"score_gpt":0.2590996976331145,"score_spread":0.2409796632861141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}