{"id":"W2318040934","doi":"10.1021/ml500260j","title":"Conjugation and Evaluation of Small Hydrophobic Molecules to Triazole-Linked siRNAs","year":2014,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Small interfering RNA; Gene silencing; RNA interference; Chemistry; Luciferase; Cell biology; RNA; Transfection; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004020912,0.000350679,0.000223381,0.0001958929,0.0001699648,0.0002019489,0.0002043989,0.0003365966,0.0005471154],"category_scores_gemma":[0.0003628742,0.0001442687,0.0002238838,0.0002104576,0.0002211739,0.0001972512,0.0001512212,0.0002163903,0.0001934168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847195,"about_ca_system_score_gemma":0.0002133783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009813107,"about_ca_topic_score_gemma":0.001124207,"domain_scores_codex":[0.9997576,0.00007338948,0.00002566938,0.00003519587,0.00007287463,0.00003537749],"domain_scores_gemma":[0.9998183,0.00004016711,0.00005303526,0.00001962426,0.00004278655,0.00002608669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005297627,0.0000344455,0.00005221516,0.0000242938,0.000002937908,0.00003519865,0.000016727,0.0001386127,0.9990891,0.00002242686,0.000005897169,0.0005251337],"study_design_scores_gemma":[0.00001070093,0.0007622781,0.0005530423,0.000001244281,0.000008738423,0.00005265809,0.000007995713,0.0004400881,0.9979038,0.000005091155,0.0002513922,0.00000310103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966472,0.0004263918,0.002212629,0.00002269875,0.000009680265,0.00007660368,0.00004953212,0.00002408406,0.0005313504],"genre_scores_gemma":[0.9944845,0.0007423003,0.003298977,0.00002279207,0.000005533584,0.00005769873,0.0001310037,0.000010658,0.001246533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009813107,"threshold_uncertainty_score":0.002126515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01812003434700045,"score_gpt":0.2590996976331145,"score_spread":0.2409796632861141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}