{"id":"W2318062538","doi":"10.1021/bi500679c","title":"Conformational Selection and Functional Dynamics of Calmodulin: A <sup>19</sup>F Nuclear Magnetic Resonance Study","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Calmodulin; Chemistry; Bound state; Nuclear magnetic resonance spectroscopy; Peptide; Relaxation (psychology); Crystallography; Biophysics; Calcium; Stereochemistry; Biochemistry; Physics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300343,0.0001435583,0.0001295198,0.00002314038,0.00008616695,0.00001699318,0.0000958585,0.0001714353,0.00003580195],"category_scores_gemma":[0.0001008266,0.0001465318,0.0000437618,0.00007189527,0.00009462171,0.000004864143,0.00008670872,0.00009631491,0.000002059954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002327398,"about_ca_system_score_gemma":0.00006363147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001665819,"about_ca_topic_score_gemma":0.00001083395,"domain_scores_codex":[0.9991672,0.00002676146,0.0002182962,0.0002787871,0.0001643794,0.0001445776],"domain_scores_gemma":[0.9995089,0.00001097006,0.00007892238,0.0002133613,0.000111338,0.00007656909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001445576,0.0007286584,0.09447846,0.0005324631,0.0001961052,0.000003844402,0.0004059128,0.002430707,0.8478673,0.004119282,0.004394489,0.04339718],"study_design_scores_gemma":[0.01062293,0.004859087,0.1532965,0.0001183112,0.0002564018,0.0007357509,0.002353379,0.5854555,0.1938681,0.002688759,0.0433923,0.002352995],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967142,0.0004013976,0.001630441,0.00005188741,0.00003119474,0.0001489032,0.00004760385,0.00001457798,0.0009598196],"genre_scores_gemma":[0.9981394,0.00002314444,0.0009641594,0.00008982042,0.0001800809,0.00001217072,0.0002002311,0.00001501284,0.000375998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6539992,"threshold_uncertainty_score":0.5975392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00344382518472939,"score_gpt":0.1960174337374107,"score_spread":0.1925736085526813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}