{"id":"W2318097039","doi":"10.1021/om300354x","title":"1,1′-Disubstituted Ferrocenyl Carbohydrate Chloroquine Conjugates as Potential Antimalarials","year":2012,"lang":"en","type":"article","venue":"Organometallics","topic":"Ferrocene Chemistry and Applications","field":"Chemistry","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF; Advanced Applied Physics Solutions; University of British Columbia","funders":"","keywords":"Chemistry; Ferrocene; Moiety; Stereochemistry; Plasmodium falciparum; Chloroquine; Reductive amination; Conjugate; Combinatorial chemistry; Structural isomer; Adamantane; Organic chemistry; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001459767,0.0003360816,0.0003508586,0.00004683459,0.0002499007,0.00008207161,0.0004072626,0.0002074847,0.009986149],"category_scores_gemma":[0.0001362026,0.0003386954,0.0001435198,0.000376342,0.0001478912,0.0003323246,0.0001387357,0.0002549285,0.0009775171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006465145,"about_ca_system_score_gemma":0.00008338202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000021511,"about_ca_topic_score_gemma":0.000001271191,"domain_scores_codex":[0.9982787,0.00001037733,0.0004126211,0.0003759719,0.0002700701,0.0006522871],"domain_scores_gemma":[0.9987228,0.00004185909,0.0001746425,0.0005845844,0.0001079667,0.000368129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001892571,0.0002912408,0.00105637,0.00008835986,0.00009934552,0.000007869322,0.0000899464,0.00002437973,0.9953696,0.002473594,0.0002366966,0.0002437043],"study_design_scores_gemma":[0.0004911763,0.000007443623,0.0006879604,0.00001778446,0.0001553777,0.00005305541,0.0001192453,0.00008256212,0.9734289,0.0003134831,0.02419864,0.0004443533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625508,0.0008546949,0.0001208766,0.0003618484,0.0001881146,0.00008839565,0.00008244759,0.0002811735,0.0354717],"genre_scores_gemma":[0.9932978,0.0001166888,0.0004002738,0.0001421312,0.000768015,0.00004553101,0.0005133764,0.00006574352,0.004650465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03082124,"threshold_uncertainty_score":0.9999065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194169449514436,"score_gpt":0.2407638947807559,"score_spread":0.2288222002856116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}