{"id":"W2318102135","doi":"10.1158/1538-7445.am2012-3018","title":"Abstract 3018: Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through GnRH-I receptor and mitogen-activated protein kinases (MAPKs)-dependent activation of matrix metalloproteinase (MMP)-2","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Agonist; Endometrial cancer; Motility; Internal medicine; Cancer research; Angiogenesis; Metastasis; Endocrinology; Gonadotropin-releasing hormone; Receptor; Kinase; MAPK/ERK pathway; Medicine; Cancer; Biology; Chemistry; Luteinizing hormone; Hormone; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009968211,0.0003658557,0.0003559802,0.0001400048,0.0001276725,0.0002163542,0.0001799722,0.0002555833,0.005807871],"category_scores_gemma":[0.0001033806,0.0001425426,0.0003708327,0.0001826633,0.0001485359,0.0001399601,0.0001411422,0.0005841954,0.001290403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001614682,"about_ca_system_score_gemma":0.0002705978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003690877,"about_ca_topic_score_gemma":0.0004449547,"domain_scores_codex":[0.9999149,0.00001178002,0.00001076104,0.0000153878,0.00002892018,0.00001822606],"domain_scores_gemma":[0.9999571,0.000005344036,0.000009860752,0.000003245634,0.000006251739,0.00001824688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001120374,0.0001447654,0.0006302872,0.0004988125,0.0000251868,0.0003664535,0.00002511937,0.00003354707,0.9914289,0.00009026803,0.001345938,0.004290196],"study_design_scores_gemma":[0.0009446685,0.004937583,0.0661342,0.0001170797,0.0002028765,0.003839313,0.0002744155,0.001324507,0.887581,0.0002113944,0.03440844,0.00002455814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648561,0.01753021,0.002461039,0.001159902,0.0009115444,0.0001647855,0.003498278,0.0002281769,0.009189921],"genre_scores_gemma":[0.9505182,0.01140448,0.003844427,0.0008324792,0.0003204986,0.0003159959,0.006977492,0.00006353846,0.02572301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005807871,"threshold_uncertainty_score":0.01942927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0415120190202113,"score_gpt":0.3480371772451675,"score_spread":0.3065251582249562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}