{"id":"W2318124317","doi":"10.1097/coh.0b013e328356db89","title":"Resistance to HIV integrase inhibitors","year":2012,"lang":"en","type":"review","venue":"Current Opinion in HIV and AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research; Canadian Foundation for AIDS Research; amfAR, The Foundation for AIDS Research","keywords":"Elvitegravir; Integrase; Raltegravir; Integrase inhibitor; Biology; Genetics; Mutation; Drug resistance; Computational biology; Virology; Gene; Virus; Antiretroviral therapy; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005333046,0.0007635328,0.001278409,0.0008597563,0.0001800098,0.001446754,0.0007723807,0.001007291,0.009612026],"category_scores_gemma":[0.001157197,0.0001960267,0.0004881895,0.0008483867,0.0002884849,0.0008705404,0.0005771294,0.001404442,0.00620581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005402484,"about_ca_system_score_gemma":0.000943367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00042653,"about_ca_topic_score_gemma":0.0004987752,"domain_scores_codex":[0.9996254,0.00007135855,0.00005225326,0.00005773586,0.0001592054,0.00003400337],"domain_scores_gemma":[0.9994339,0.0001758825,0.0001287501,0.00001558874,0.0002007195,0.00004503795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000983072,0.00003745996,0.0002095675,0.02272947,0.000137569,0.0002238148,0.00005533283,0.0002531154,0.001910802,0.002002038,0.1420935,0.8302491],"study_design_scores_gemma":[0.00001943135,0.00006697779,0.0004463275,0.004455008,0.0001045864,0.001036689,0.00002893827,0.00006827178,0.0006585048,0.0006159873,0.992489,0.00001035797],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000229683,0.9931957,0.0002324359,0.001286439,0.00183556,0.00002042328,0.0001146161,0.00002863192,0.003056625],"genre_scores_gemma":[0.00195926,0.9915829,0.0002803266,0.001776629,0.001935966,0.00002217653,0.0002374712,0.00001025682,0.002194955],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009612026,"threshold_uncertainty_score":0.03215539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08433393700583193,"score_gpt":0.3806411832473745,"score_spread":0.2963072462415426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}