{"id":"W2318268630","doi":"10.1158/0008-5472.sabcs10-p5-05-01","title":"Abstract P5-05-01: IGFBP-7 Reduces Growth of Xenografted Breast Tumors in Mice and Inhibits Breast Cancer Cell Proliferation and Migration through the MEK-ERK Pathway","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Cancer research; Triple-negative breast cancer; Breast cancer; Ectopic expression; Cyclin-dependent kinase 6; Cell growth; Biology; Metastasis; Cancer; Carcinogenesis; Cyclin D1; Cell culture; Cell cycle; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002133639,0.0006566344,0.0005505332,0.0005815116,0.0002194337,0.0003810112,0.0003829784,0.000518342,0.006105317],"category_scores_gemma":[0.0001399479,0.0002283459,0.0005151483,0.0002461495,0.0003144032,0.0002299737,0.0001937515,0.001489885,0.001131321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005612819,"about_ca_system_score_gemma":0.000577037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002205598,"about_ca_topic_score_gemma":0.003697064,"domain_scores_codex":[0.9997233,0.00004015958,0.00002237544,0.00003553245,0.0000942906,0.00008434698],"domain_scores_gemma":[0.9998307,0.00001867284,0.00003825707,0.00001618489,0.00002159388,0.00007456188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00134084,0.0005345872,0.0002136276,0.0001241113,0.00002797407,0.00006835688,0.00001546104,0.00008863357,0.9938369,0.00009267111,0.0006762792,0.002980494],"study_design_scores_gemma":[0.0003196509,0.005888829,0.007524926,0.00001779981,0.00009206851,0.0003872645,0.00005554955,0.00133884,0.9787642,0.00005589171,0.00554328,0.00001166477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835127,0.00310585,0.003054966,0.0008036238,0.0003058437,0.000144842,0.004539855,0.0006396156,0.003892645],"genre_scores_gemma":[0.9683423,0.002252898,0.005408749,0.0004059205,0.00006973762,0.0002381237,0.006002432,0.0001321289,0.01714786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006105317,"threshold_uncertainty_score":0.02042425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800406715136714,"score_gpt":0.3071720431414859,"score_spread":0.2891679759901188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}