{"id":"W2318305503","doi":"10.1158/1538-7445.am2013-681","title":"Abstract 681: SGI-110, a novel 5-aza-2’-deoxycytidine- containing dinucleotide, induces Cancer Germline (CG) antigen expression in Acute Myeloid Leukemia (AML) cells.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Demethylating agent; DNA methylation; Cancer research; Molecular biology; HL60; Bisulfite sequencing; Myeloid leukemia; Biology; Decitabine; CpG site; Cancer; Viability assay; Leukemia; Cell culture; Gene expression; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000947131,0.0003093448,0.0002216914,0.0001394207,0.00008856484,0.0001381084,0.0001467371,0.000217792,0.002198006],"category_scores_gemma":[0.00005873324,0.0001018185,0.0001673207,0.0001312974,0.0001447085,0.00007066555,0.0001035493,0.0003749988,0.0007108671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002535956,"about_ca_system_score_gemma":0.000168771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006348423,"about_ca_topic_score_gemma":0.0006498023,"domain_scores_codex":[0.9999125,0.00001320601,0.000008579297,0.00002081897,0.00002627843,0.00001865325],"domain_scores_gemma":[0.9999527,0.00001208024,0.00001118258,0.000006564735,0.000004944101,0.00001259008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001333026,0.00004036629,0.0001124695,0.00002866862,0.000002191027,0.00001858076,0.000009540487,0.00003619764,0.9981517,0.00003952156,0.0001220413,0.001305524],"study_design_scores_gemma":[0.00002907036,0.0007527633,0.001965698,0.000002541979,0.00000774836,0.00009415142,0.000005597863,0.0003178517,0.9946802,0.00001508097,0.002128173,0.000001084145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904684,0.001107397,0.002613722,0.0001258169,0.00005759257,0.00008662703,0.001477476,0.0002654283,0.003797505],"genre_scores_gemma":[0.9860355,0.0007167661,0.002382482,0.00008654754,0.00001628527,0.00008746358,0.003655133,0.00003292454,0.006986948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002198006,"threshold_uncertainty_score":0.007353067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05006184931254794,"score_gpt":0.3578362199487513,"score_spread":0.3077743706362033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}