{"id":"W2318366158","doi":"10.1042/bst20130215","title":"New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases","year":2014,"lang":"en","type":"article","venue":"Biochemical Society Transactions","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Canadian Institutes of Health Research; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Cullin; Ubiquitin; Ubiquitin ligase; KEAP1; NEDD8; Ubiquitin-Protein Ligases; Regulator; Proteasome; Cell biology; Biology; Biochemistry; Chemistry; Gene; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002170331,0.0006230925,0.0004014776,0.0003878035,0.0001909824,0.0003756249,0.000472503,0.0003825427,0.003711479],"category_scores_gemma":[0.00009917741,0.00019042,0.0003033986,0.0002339995,0.0002548278,0.0004330412,0.0003098699,0.0009817488,0.0009035453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004590107,"about_ca_system_score_gemma":0.0002515213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006269511,"about_ca_topic_score_gemma":0.002159808,"domain_scores_codex":[0.9999014,0.00001446163,0.000006276571,0.00002069246,0.00003190416,0.00002518938],"domain_scores_gemma":[0.9999667,0.000006307368,0.000006645873,0.000004149409,0.000006841036,0.000009300197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000738001,0.0004396319,0.000261389,0.0009696136,0.0001171718,0.0003909088,0.00007887971,0.001795,0.8678922,0.01074535,0.005989072,0.1105827],"study_design_scores_gemma":[0.0004850687,0.001797249,0.001785281,0.00008080446,0.0001112567,0.00125947,0.00005113547,0.003689888,0.7476358,0.002460921,0.2406071,0.00003602712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5652588,0.2454014,0.08341646,0.00647444,0.002651137,0.00115461,0.002039691,0.001757579,0.09184588],"genre_scores_gemma":[0.8311121,0.08232487,0.02036401,0.002509234,0.0002557682,0.0005208175,0.001168233,0.0001039823,0.06164087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003711479,"threshold_uncertainty_score":0.01241618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007472558069221999,"score_gpt":0.2279238332716927,"score_spread":0.2204512752024707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}