{"id":"W2318421360","doi":"10.1093/neuonc/nov061.112","title":"MB-36 * WIP1 AUGMENTS SONIC HEDGEHOG (SHH) SIGNALING AND IS A TARGET IN SHH MEDULLOBLASTOMAS","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Sonic hedgehog; Medulloblastoma; Hedgehog signaling pathway; Cell biology; Hedgehog; Cancer research; Biology; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008324688,0.0003434992,0.0002534505,0.0003513616,0.0002054082,0.0002110681,0.0002001325,0.0002226604,0.002980945],"category_scores_gemma":[0.00006738977,0.0001581926,0.0002413915,0.0001513083,0.0001913371,0.0001249263,0.0001852789,0.0005361044,0.0008476041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004176385,"about_ca_system_score_gemma":0.0002380512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002026705,"about_ca_topic_score_gemma":0.002375809,"domain_scores_codex":[0.9998652,0.00001156221,0.00001240839,0.00002736864,0.00004534379,0.00003819601],"domain_scores_gemma":[0.999925,0.00000646736,0.00001406394,0.000006440438,0.000006207973,0.00004179117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096635,0.00003074138,0.0001719503,0.00002335358,0.000003088347,0.00004054679,0.000005374325,0.00003606158,0.9984595,0.00007378962,0.00009839156,0.0009477107],"study_design_scores_gemma":[0.00002590914,0.0003943029,0.005202937,0.000004718098,0.00001646771,0.0003374033,0.00001956231,0.0004676268,0.9858683,0.00004099825,0.007617733,0.000004081087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879867,0.002857767,0.002772344,0.0003934617,0.00008295239,0.00006553719,0.002221559,0.0002947626,0.003324978],"genre_scores_gemma":[0.9811141,0.001301261,0.003620476,0.00008864944,0.00001882332,0.00006994287,0.002641942,0.00004139412,0.01110337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002980945,"threshold_uncertainty_score":0.009972274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0306727920107308,"score_gpt":0.2955852326453178,"score_spread":0.264912440634587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}