{"id":"W2318573097","doi":"10.3851/imp2685","title":"Significant Interaction between Activated Charcoal and Antiretroviral Therapy Leading to Subtherapeutic Drug Concentrations, Virological Breakthrough and Development of Resistance","year":2013,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"Poisoning and overdose treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Toronto General Hospital; University of Toronto","funders":"","keywords":"Antiretroviral therapy; Drug resistance; Drug; Charcoal; Medicine; Antiretroviral drug; Human immunodeficiency virus (HIV); Internal medicine; Pharmacology; Virology; Viral load; Intensive care medicine; Biology; Chemistry; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002571182,0.0003165498,0.0003656088,0.0004213752,0.000720276,0.0003911768,0.0002065634,0.0006668863,0.001750484],"category_scores_gemma":[0.001470687,0.0001936385,0.0004491574,0.0003926546,0.0002592121,0.0002471977,0.0002199624,0.0008296588,0.000213202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005598758,"about_ca_system_score_gemma":0.0004844628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002371281,"about_ca_topic_score_gemma":0.004353345,"domain_scores_codex":[0.9996238,0.0001086475,0.00004466749,0.0000403869,0.0001014492,0.00008107343],"domain_scores_gemma":[0.99906,0.0003793266,0.0002605516,0.00004450928,0.00008829831,0.0001673672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.002827131,0.0009321,0.4739323,0.0001730137,0.0003160499,0.4813407,0.0003939989,0.0005906512,0.0119453,0.0006984572,0.001444291,0.02540588],"study_design_scores_gemma":[0.0001875144,0.003492683,0.3476171,0.00006796127,0.0003917326,0.6285044,0.0003364632,0.003797668,0.007969973,0.0006078867,0.006968107,0.00005848814],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911142,0.001608242,0.0006562128,0.0008909935,0.00004334227,0.0000478069,0.0000921379,0.0000343381,0.005512713],"genre_scores_gemma":[0.9987257,0.0002598524,0.0002236317,0.0001582985,0.00003597624,0.000002682101,0.00003918203,0.00000329711,0.000551482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002371281,"threshold_uncertainty_score":0.005855978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05142089867741031,"score_gpt":0.3157021093530544,"score_spread":0.2642812106756441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}