{"id":"W2318573097","doi":"10.3851/imp2685","title":"Significant Interaction between Activated Charcoal and Antiretroviral Therapy Leading to Subtherapeutic Drug Concentrations, Virological Breakthrough and Development of Resistance","year":2013,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"Poisoning and overdose treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Toronto General Hospital; University of Toronto","funders":"","keywords":"Antiretroviral therapy; Drug resistance; Drug; Charcoal; Medicine; Antiretroviral drug; Human immunodeficiency virus (HIV); Internal medicine; Pharmacology; Virology; Viral load; Intensive care medicine; Biology; Chemistry; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001296468,0.000210783,0.0003933396,0.00008004587,0.000140951,0.00004121486,0.0000559559,0.00007519058,0.00002841191],"category_scores_gemma":[0.00001048961,0.0001547609,0.00003709933,0.0001372225,0.0001188722,0.0002345479,0.00001784411,0.0001407844,0.00001617326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004927931,"about_ca_system_score_gemma":0.00004805292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008351362,"about_ca_topic_score_gemma":0.000004748213,"domain_scores_codex":[0.9988457,0.00008733254,0.0003062223,0.0003202842,0.0001764306,0.0002640327],"domain_scores_gemma":[0.9994893,0.0001072445,0.000112864,0.0001400071,0.00005618597,0.00009436429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005204016,0.0001463981,0.3857958,0.00001347789,0.0001801962,0.000002828546,0.00260681,1.207039e-7,0.4894137,0.0000337877,0.00006633061,0.1212202],"study_design_scores_gemma":[0.002171739,0.0006266038,0.635169,0.0001100795,0.0000127701,0.000003139782,0.0003475067,0.000007352023,0.359755,0.00003426297,0.001603666,0.000158937],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976344,0.0007116477,0.0001314313,0.0006053946,0.00004472694,0.0006475368,0.000005787512,0.00005183817,0.00016725],"genre_scores_gemma":[0.9973542,0.0007823071,0.001111461,0.0003402259,0.00005112301,0.0000327511,0.00002460061,0.00002031705,0.0002830285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2493732,"threshold_uncertainty_score":0.6310965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05142089867741031,"score_gpt":0.3157021093530544,"score_spread":0.2642812106756441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}