{"id":"W2318687605","doi":"10.1021/bi500784g","title":"Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein C and Its Hypertrophic Cardiomyopathy-Related R502W Mutant","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Canada Foundation for Innovation","keywords":"Sarcomere; Hypertrophic cardiomyopathy; Mutant; Mutation; Myosin; Cardiac muscle; Immunoglobulin domain; Biology; Cell biology; Chemistry; Genetics; Myocyte; Gene; Biochemistry; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008834225,0.0002098879,0.0001082721,0.0001110745,0.0001882776,0.00007972166,0.0002208349,0.0002980363,0.0006318484],"category_scores_gemma":[0.0001842372,0.0000732714,0.0002125296,0.0001421136,0.0001632765,0.00009449577,0.0001071915,0.0002658077,0.0001798854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002259063,"about_ca_system_score_gemma":0.0001516291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00281568,"about_ca_topic_score_gemma":0.001766948,"domain_scores_codex":[0.9999559,0.000005903828,0.000002567735,0.000009548193,0.00001377351,0.00001214547],"domain_scores_gemma":[0.9998926,0.00002069733,0.00002724834,0.000009362707,0.00001993942,0.0000300964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001613649,0.00004511068,0.001194169,0.00002745807,0.00000955356,0.0003346497,0.00004859973,0.0003982254,0.9966429,0.0001189476,0.0001289593,0.0008900932],"study_design_scores_gemma":[0.0000751372,0.0006256023,0.1093862,0.00002801745,0.0000654376,0.003953227,0.0002408988,0.01598433,0.8639009,0.0002625594,0.005435581,0.00004215901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987965,0.0001818557,0.0004015177,0.00003770919,0.000006913641,0.000004685402,0.0001767682,0.000006520869,0.0003876083],"genre_scores_gemma":[0.9977353,0.00009264425,0.0007045527,0.00005373714,0.000004581652,0.000006836969,0.0009032807,0.000009916634,0.0004890697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00281568,"threshold_uncertainty_score":0.005598545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006627132166840059,"score_gpt":0.2045771978648688,"score_spread":0.1979500656980288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}