{"id":"W2318688580","doi":"10.1021/jm5003843","title":"Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1 <i>H</i> -pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Drug Abuse; National Institute of Mental Health","keywords":"Neurotensin; Chemistry; Cyclohexane; Carboxylic acid; Peptide; Receptor; Stereochemistry; Amino acid; Chemical synthesis; Pharmacology; Biochemistry; In vitro; Neuropeptide; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127557,0.0003112757,0.0003490011,0.0002452918,0.0001850399,0.0001817041,0.0003065855,0.0002728324,0.002590508],"category_scores_gemma":[0.000129617,0.0001108443,0.0002145581,0.0001701241,0.0001615775,0.0001952675,0.0001586355,0.0003754336,0.0006392383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002705225,"about_ca_system_score_gemma":0.0004984941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159439,"about_ca_topic_score_gemma":0.003073459,"domain_scores_codex":[0.9999138,0.00001517265,0.000006000906,0.00001669469,0.00002067468,0.00002768365],"domain_scores_gemma":[0.9999266,0.000008394226,0.00001513729,0.000005183976,0.00001839156,0.00002640571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003612138,0.0001305109,0.0001409832,0.0001257939,0.000007124475,0.0002802901,0.00002585064,0.0001332237,0.9944746,0.0002056982,0.0001137786,0.004000923],"study_design_scores_gemma":[0.0003745216,0.005659049,0.006320376,0.0000289561,0.00005277063,0.001165084,0.00004556385,0.0008772826,0.9769284,0.00008036337,0.008444416,0.00002328257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786162,0.006233111,0.004766334,0.0003045957,0.0001212833,0.0003767428,0.001046685,0.0001043081,0.008430664],"genre_scores_gemma":[0.9828012,0.003593566,0.006209794,0.0001816407,0.00004671816,0.000140405,0.001270378,0.00001566898,0.005740659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002590508,"threshold_uncertainty_score":0.008666098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01424316870275675,"score_gpt":0.2605980255185985,"score_spread":0.2463548568158417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}