{"id":"W2318763430","doi":"10.1097/pai.0000000000000089","title":"Protein Expression for Novel Prognostic Markers (Cyclins D1, D2, D3, B1, B2, ITGβ7, FGFR3, PAX5) Correlate With Previously Reported Gene Expression Profile Patterns in Plasma Cell Myeloma","year":2014,"lang":"en","type":"article","venue":"Applied immunohistochemistry & molecular morphology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; Foothills Medical Centre; University of Calgary","funders":"","keywords":"Cyclin D1; Cyclin; Multiple myeloma; Cyclin D3; Immunohistochemistry; Plasma Cell Myeloma; Cyclin D2; Cancer research; Gene expression; Pathology; Biology; Medicine; Cell cycle; Oncology; Molecular biology; Cancer; Gene; Immunology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004337682,0.0007136492,0.0009246462,0.0001938737,0.0001999434,0.00003520578,0.0003865172,0.0005669596,0.00015811],"category_scores_gemma":[0.0003646911,0.0006134358,0.0002108522,0.0002709344,0.000256899,0.00006382978,0.0002339717,0.0007540481,0.00003516248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004208021,"about_ca_system_score_gemma":0.0003457877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006853298,"about_ca_topic_score_gemma":0.000001054935,"domain_scores_codex":[0.9956362,0.0001041559,0.0009579636,0.001469675,0.0006127137,0.001219257],"domain_scores_gemma":[0.997123,0.0001665206,0.0006103533,0.001475319,0.0002101009,0.0004147073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006180717,0.00126788,0.003299889,0.0007414336,0.0001565618,0.0009420326,0.0001146453,0.00003532269,0.9855956,0.000004491844,0.0002294352,0.001432019],"study_design_scores_gemma":[0.01625142,0.001021035,0.005622296,0.0007434165,0.0001867389,0.0005802764,0.00008827056,0.0006128183,0.9741392,0.00001647293,0.0001741746,0.0005639297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738019,0.0002297486,0.01758466,0.0001038848,0.00007879398,0.00630917,0.00007054107,0.0001487207,0.001672594],"genre_scores_gemma":[0.9659144,0.00001701378,0.02485528,0.000121551,0.00005856442,0.005458151,0.002013405,0.0001790554,0.001382539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01145642,"threshold_uncertainty_score":0.9996317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006944229659738,"score_gpt":0.2548551505031196,"score_spread":0.2447857082065223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}