{"id":"W2318765570","doi":"10.1042/bj20112133","title":"Steric and allosteric factors prevent simultaneous binding of transferrin-binding proteins A and B to transferrin","year":2012,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Transferrin; Allosteric regulation; Steric effects; Chemistry; Plasma protein binding; Binding site; Biochemistry; Stereochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960507,0.0001982906,0.0002033337,0.00006408103,0.00007198565,0.00003102018,0.0001438539,0.0001396403,0.00001564883],"category_scores_gemma":[0.0001423989,0.0001730748,0.00008968967,0.00008599245,0.00007955172,0.000008278395,0.00007360725,0.0001449057,0.000001102833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002299072,"about_ca_system_score_gemma":0.00003879308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002966932,"about_ca_topic_score_gemma":6.290964e-7,"domain_scores_codex":[0.9988709,0.00006077918,0.000299557,0.0002304363,0.0001819251,0.00035641],"domain_scores_gemma":[0.9992284,0.00003321162,0.00006037585,0.0001347063,0.00004037765,0.0005028836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001609479,0.0001239073,0.01009862,0.00006224264,0.00005894642,0.000005555199,0.0003901606,0.000005105529,0.9880829,0.000002507954,0.00003347334,0.0009755646],"study_design_scores_gemma":[0.0004836156,0.0003741577,0.001082621,0.00009153116,0.00005188358,0.0001977877,0.0001579859,0.000009819963,0.9969661,0.000005533226,0.0003585016,0.0002205198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973712,0.00114371,0.000993656,0.00004937875,0.00009684635,0.0002694938,0.00005088287,0.000007648398,0.00001718175],"genre_scores_gemma":[0.9987253,0.00007304255,0.0008937909,0.0000428584,0.0001811236,0.000009353846,0.00001428395,0.00002704168,0.00003320112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009015999,"threshold_uncertainty_score":0.7057787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694752595547797,"score_gpt":0.2576710228852047,"score_spread":0.2407234969297267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}