{"id":"W2318765570","doi":"10.1042/bj20112133","title":"Steric and allosteric factors prevent simultaneous binding of transferrin-binding proteins A and B to transferrin","year":2012,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Transferrin; Allosteric regulation; Steric effects; Chemistry; Plasma protein binding; Binding site; Biochemistry; Stereochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002006287,0.0001824565,0.0002189697,0.00008166287,0.0001570358,0.0002825772,0.0003449247,0.0002984628,0.001884782],"category_scores_gemma":[0.0004855528,0.0001844119,0.0002011234,0.00005689533,0.0004233858,0.0001625957,0.000277771,0.0004537317,0.0003687084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002696771,"about_ca_system_score_gemma":0.0003108208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001017176,"about_ca_topic_score_gemma":0.00116167,"domain_scores_codex":[0.9997759,0.00004901796,0.000018366,0.00004184396,0.00006576572,0.00004900291],"domain_scores_gemma":[0.9996123,0.0001558876,0.00008946069,0.0000460671,0.00003009755,0.00006616857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001879739,0.00002953109,0.0002083682,0.00002815816,0.000003853378,0.00004054542,0.00001196509,0.00005210601,0.9985135,0.0001047078,0.00004084001,0.000778451],"study_design_scores_gemma":[0.00005492205,0.0002325434,0.002942045,0.000007232554,0.00001044766,0.0002674231,0.00002997173,0.001568832,0.9928157,0.0000800088,0.001982931,0.000007926447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996439,0.0004268388,0.001710693,0.0000910138,0.00002156118,0.00002166574,0.00005427814,0.00005732843,0.00117754],"genre_scores_gemma":[0.9973829,0.0001303901,0.001410321,0.00007682145,0.000009248448,0.0000146867,0.00008528984,0.00001944087,0.0008707656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884782,"threshold_uncertainty_score":0.006305218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694752595547797,"score_gpt":0.2576710228852047,"score_spread":0.2407234969297267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}