{"id":"W2318767334","doi":"10.1021/jm100758j","title":"Preparation and Evaluation of Carborane Analogues of Tamoxifen","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Tamoxifen; Chemistry; Carborane; Estrogen receptor; Stereoselectivity; Stereochemistry; Combinatorial chemistry; Breast cancer; Biochemistry; Internal medicine; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387794,0.0001790206,0.0002510254,0.0001474104,0.0001518577,0.0001974714,0.0002201407,0.0002380051,0.001263611],"category_scores_gemma":[0.0002856252,0.00009615017,0.0001529639,0.0001511148,0.0001246113,0.0001450629,0.0001446023,0.0003122417,0.0002605218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001635891,"about_ca_system_score_gemma":0.0001439512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005089745,"about_ca_topic_score_gemma":0.001072546,"domain_scores_codex":[0.9998488,0.00003524177,0.00001381665,0.00002902129,0.0000468101,0.00002617975],"domain_scores_gemma":[0.99992,0.0000103143,0.00001578697,0.00001168204,0.0000217095,0.00002054462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003264485,0.00007231889,0.0001354001,0.00008710962,0.00001286203,0.000105064,0.0000284472,0.0002497227,0.9925073,0.000158888,0.00009319482,0.006223141],"study_design_scores_gemma":[0.00007928265,0.001705998,0.0006866238,0.000006222412,0.00001713893,0.0002409264,0.00002210187,0.0003483423,0.9890289,0.00001700867,0.007839599,0.000007940989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983715,0.004257282,0.004514353,0.0001119365,0.00009661574,0.0003064603,0.0004803481,0.00005763317,0.006460444],"genre_scores_gemma":[0.9901064,0.002225735,0.004454716,0.00006406997,0.00002321889,0.00007644683,0.000498874,0.00001976488,0.00253082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001263611,"threshold_uncertainty_score":0.004227221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03111580124236656,"score_gpt":0.3979838970114923,"score_spread":0.3668680957691258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}