{"id":"W2318767334","doi":"10.1021/jm100758j","title":"Preparation and Evaluation of Carborane Analogues of Tamoxifen","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Tamoxifen; Chemistry; Carborane; Estrogen receptor; Stereoselectivity; Stereochemistry; Combinatorial chemistry; Breast cancer; Biochemistry; Internal medicine; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009345093,0.00006904394,0.0002679334,0.00002553159,0.00001442178,0.00000178405,0.00006432065,0.00009402,0.0001783024],"category_scores_gemma":[0.000507767,0.00005430577,0.00005924645,0.0001010065,0.0001845912,0.00004151866,0.000008366208,0.0003207119,1.777972e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001924343,"about_ca_system_score_gemma":0.0002224715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002091115,"about_ca_topic_score_gemma":3.258651e-7,"domain_scores_codex":[0.9987816,0.0000139444,0.0004661748,0.0000764865,0.000595585,0.0000661662],"domain_scores_gemma":[0.9985293,0.00007219242,0.0004193688,0.0001332835,0.0007009718,0.0001448839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002112371,0.000105694,0.002406213,0.0003234532,0.00005395994,0.000003694041,0.0001210781,0.000006776222,0.9941953,0.00001018051,0.0001537215,0.002408624],"study_design_scores_gemma":[0.001586753,0.0001180005,0.006697448,0.0001538389,0.0006476715,0.0005696227,0.0001176292,0.0007110909,0.9886919,0.0002294557,0.0004365011,0.00004012505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952188,0.0008300777,0.00002519883,0.0005621625,0.00003539156,0.00007626224,0.000004021752,0.000002550263,0.003245578],"genre_scores_gemma":[0.9990627,0.0001055271,0.0003952065,0.0000196082,0.0003629332,0.000002213139,0.000007478941,0.000004444028,0.00003993681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005503505,"threshold_uncertainty_score":0.2214525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03111580124236656,"score_gpt":0.3979838970114923,"score_spread":0.3668680957691258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}