{"id":"W2318836896","doi":"10.1021/ja110246u","title":"Maximizing the Therapeutic Window of an Antimicrobial Drug by Imparting Mitochondrial Sequestration in Human Cells","year":2011,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Antimicrobial; Chemistry; Toxicity; Staphylococcus aureus; Antibiotics; Drug; Bacteria; Mitochondrial toxicity; Peptide; Microbiology; Pharmacology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003150745,0.0003182288,0.0003917679,0.0001415364,0.0001881878,0.0005570562,0.0002113638,0.0004266327,0.001226702],"category_scores_gemma":[0.0002566898,0.0001078673,0.0001541844,0.0001639269,0.0002642467,0.000359612,0.000324178,0.0003791437,0.0004063933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000391492,"about_ca_system_score_gemma":0.0003148126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002574327,"about_ca_topic_score_gemma":0.0004997575,"domain_scores_codex":[0.9997934,0.00005922686,0.00001793936,0.00004854893,0.0000506526,0.00003023714],"domain_scores_gemma":[0.9998672,0.00003758695,0.00003830687,0.00002216896,0.0000173382,0.00001749463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001334653,0.0000279137,0.0001773909,0.00007700446,0.000005283177,0.0000627723,0.00002338812,0.0001765143,0.992112,0.0005474687,0.0001067994,0.006549906],"study_design_scores_gemma":[0.00002400773,0.0005113332,0.0003597434,0.000007698296,0.00001469186,0.0003753285,0.00001454843,0.0005109981,0.9906275,0.00007657814,0.007473075,0.000004641637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9383231,0.01721933,0.03732413,0.0008743234,0.0001350775,0.0001576173,0.0002506905,0.0002774388,0.00543814],"genre_scores_gemma":[0.9831485,0.003545098,0.01192538,0.0001088919,0.00002945641,0.00004417897,0.00009408952,0.00001743746,0.001087068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226702,"threshold_uncertainty_score":0.00410372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01461898699818647,"score_gpt":0.2580435376639935,"score_spread":0.243424550665807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}