{"id":"W2318896360","doi":"10.1021/acs.est.6b01137","title":"Chronic Exposure of Marine Medaka (<i>Oryzias melastigma</i>) to 4,5-Dichloro-2-<i>n</i>-octyl-4-isothiazolin-3-one (DCOIT) Reveals Its Mechanism of Action in Endocrine Disruption via the Hypothalamus-Pituitary-Gonadal-Liver (HPGL) Axis","year":2016,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Marine Biology and Environmental Chemistry","field":"Engineering","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"China Ocean Mineral Resources Research and Development Association; National Natural Science Foundation of China","keywords":"Endocrine system; Hormone; Vitellogenin; Biology; Homeostasis; Testosterone (patch); Offspring; Tributyltin; Internal medicine; Triclosan; Downregulation and upregulation; Endocrinology; Leydig cell; Fish <Actinopterygii>; Chemistry; Gene; Ecology; Pregnancy; Medicine; Biochemistry; Luteinizing hormone; Fishery; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003766601,0.0003023907,0.0003646918,0.000335057,0.0001117705,0.000004327708,0.0007639311,0.0002169662,0.0007777796],"category_scores_gemma":[0.00004955386,0.0002261008,0.00007041585,0.0005927627,0.001208144,0.0002605621,0.0006758498,0.0002977354,0.0000767456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007161288,"about_ca_system_score_gemma":0.00002282001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000472429,"about_ca_topic_score_gemma":0.0002022435,"domain_scores_codex":[0.9979284,0.00003105714,0.00054107,0.0005314748,0.0003700473,0.0005979391],"domain_scores_gemma":[0.9990565,0.00006625678,0.0001484876,0.0006115742,0.000007281727,0.0001098844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002744449,0.0000870916,0.01676664,0.00004054874,0.00001944282,0.000007551848,0.0000514866,0.000321931,0.951251,0.0005199689,0.000004293683,0.03090262],"study_design_scores_gemma":[0.0005609286,0.0003059221,0.0847085,0.00005368939,0.00001997153,0.00007734112,0.00009773095,0.0002014034,0.9117857,0.001336288,0.0005908081,0.000261692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965991,0.000533736,0.001128292,0.0004847944,0.0001857916,0.0004230721,0.00004348464,0.00009520593,0.0005065107],"genre_scores_gemma":[0.9979003,0.001286546,0.0003883514,0.00002709624,0.00005449973,0.00009750718,0.000009922168,0.00002799572,0.0002078023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06794187,"threshold_uncertainty_score":0.9220124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007332148019978113,"score_gpt":0.1939009938877397,"score_spread":0.1865688458677615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}