{"id":"W2318896360","doi":"10.1021/acs.est.6b01137","title":"Chronic Exposure of Marine Medaka (<i>Oryzias melastigma</i>) to 4,5-Dichloro-2-<i>n</i>-octyl-4-isothiazolin-3-one (DCOIT) Reveals Its Mechanism of Action in Endocrine Disruption via the Hypothalamus-Pituitary-Gonadal-Liver (HPGL) Axis","year":2016,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Marine Biology and Environmental Chemistry","field":"Engineering","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"China Ocean Mineral Resources Research and Development Association; National Natural Science Foundation of China","keywords":"Endocrine system; Hormone; Vitellogenin; Biology; Homeostasis; Testosterone (patch); Offspring; Tributyltin; Internal medicine; Triclosan; Downregulation and upregulation; Endocrinology; Leydig cell; Fish <Actinopterygii>; Chemistry; Gene; Ecology; Pregnancy; Medicine; Biochemistry; Luteinizing hormone; Fishery; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004602387,0.0002933955,0.0001924001,0.0001291679,0.0001678231,0.0002050704,0.0001625351,0.0002664385,0.001124368],"category_scores_gemma":[0.00006070174,0.0001280088,0.0002557313,0.00006727022,0.0002715347,0.0002085422,0.0002011957,0.0004162472,0.0001735097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003164228,"about_ca_system_score_gemma":0.0002676009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002671179,"about_ca_topic_score_gemma":0.005733287,"domain_scores_codex":[0.9999466,0.000004189872,0.000003848901,0.00001964828,0.000009020732,0.0000166909],"domain_scores_gemma":[0.9999408,0.000005619001,0.00001771171,0.000006550672,0.0000104153,0.00001896869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002272957,0.00001487941,0.0005806396,0.0000277915,0.00000557472,0.00003661341,0.00002049707,0.00002559873,0.9984835,0.00001373164,0.0000178954,0.0005458736],"study_design_scores_gemma":[0.00002620149,0.002929775,0.03276029,0.00001051129,0.00005155791,0.0002087986,0.0002906341,0.0003380652,0.9612852,0.0000469236,0.002036216,0.0000157927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981501,0.0005450067,0.0003950411,0.00007362711,0.00002316225,0.00001508405,0.0002079296,0.00002867457,0.0005614157],"genre_scores_gemma":[0.9953749,0.0006289444,0.0006015035,0.0001001519,0.000007914803,0.00003058731,0.0003641662,0.000007113239,0.00288487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002671179,"threshold_uncertainty_score":0.005311251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007332148019978113,"score_gpt":0.1939009938877397,"score_spread":0.1865688458677615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}