{"id":"W2318971865","doi":"10.1097/00008390-200010000-00013","title":"TYRP2-mediated resistance to cis-diamminedichloroplatinum (II) in human melanoma cells is independent of tyrosinase and TYRP1 expression and melanin content","year":2000,"lang":"en","type":"article","venue":"Melanoma Research","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Medical Protective Association; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Medical Research Council Canada","keywords":"Melanin; Tyrosinase; Melanoma; Melanocyte; Enzyme; Cell culture; Chemistry; Cancer research; Ectopic expression; Biology; Biochemistry; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119916,0.000297861,0.0001849483,0.0001670656,0.0001442505,0.0003195395,0.00009227698,0.0001918064,0.001196745],"category_scores_gemma":[0.0001211198,0.0001834572,0.00016731,0.0001338563,0.0001598843,0.00009989735,0.0001464168,0.0003255649,0.0004284963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002009018,"about_ca_system_score_gemma":0.0001434733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007515516,"about_ca_topic_score_gemma":0.0007239608,"domain_scores_codex":[0.9998782,0.0000271777,0.000009217602,0.00003059289,0.00003149147,0.00002345236],"domain_scores_gemma":[0.9999316,0.00001287944,0.00001281637,0.00001956254,0.000009450323,0.00001373109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000545562,0.00001051085,0.0001495176,0.000009115309,0.000003016202,0.00004160166,0.000009491067,0.00001762999,0.9992577,0.00002498649,0.00002137701,0.0004005262],"study_design_scores_gemma":[0.00001936127,0.0002406587,0.006152511,0.000002198643,0.00000930913,0.000705595,0.00001668939,0.0006280252,0.9906803,0.00002208723,0.001521164,0.000002159286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959741,0.001025679,0.001451493,0.00004444461,0.00001240058,0.00002799378,0.0002580816,0.00005515297,0.001150678],"genre_scores_gemma":[0.9961205,0.0004451568,0.0007886264,0.00001699858,0.000004234518,0.00003171966,0.0005288314,0.00001190849,0.002051971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001196745,"threshold_uncertainty_score":0.004003525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03608608563245317,"score_gpt":0.3114143932873532,"score_spread":0.2753283076549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}