{"id":"W2319059017","doi":"10.1021/ol301178r","title":"A Versatile Scaffold for Site-Specific Modification of Cyclic Tetrapeptides","year":2012,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Tripeptide; Scaffold; Regioselectivity; Azide; Nucleophile; Combinatorial chemistry; Residue (chemistry); Homogeneous; Cyclic peptide; Amino acid residue; Amino acid; Stereochemistry; Peptide; Peptide sequence; Organic chemistry; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183146,0.0003931337,0.0002093682,0.0002110128,0.0001481881,0.0002166758,0.0002830145,0.0002703023,0.001334657],"category_scores_gemma":[0.000144328,0.0001366534,0.0001583631,0.0001445238,0.0001652585,0.0002318654,0.0002722397,0.0004647552,0.0004735258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001372478,"about_ca_system_score_gemma":0.0001262147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001437088,"about_ca_topic_score_gemma":0.0002433029,"domain_scores_codex":[0.9999287,0.000008787903,0.000005048787,0.0000182936,0.00001945014,0.0000198083],"domain_scores_gemma":[0.9999062,0.00001594784,0.0000298405,0.00001486761,0.000008803239,0.00002438821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003240141,0.00001080883,0.00002762647,0.00004519372,0.000003218462,0.0001085625,0.00001541644,0.000181955,0.9952596,0.0005008434,0.00008496164,0.003729476],"study_design_scores_gemma":[0.00001563468,0.0002805725,0.0004666097,0.000004581529,0.000007841141,0.0003759848,0.000007266367,0.0007441288,0.9921691,0.0001902079,0.00572789,0.00001022949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9272757,0.0025402,0.05886743,0.0003207197,0.0001642528,0.00009462193,0.0009391548,0.0008184446,0.008979444],"genre_scores_gemma":[0.9743325,0.001038668,0.02061859,0.000110861,0.00003307874,0.0000528509,0.0005517263,0.00006746866,0.003194249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001334657,"threshold_uncertainty_score":0.004464924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412515764952416,"score_gpt":0.2286891857178217,"score_spread":0.2145640280682976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}