{"id":"W2319059017","doi":"10.1021/ol301178r","title":"A Versatile Scaffold for Site-Specific Modification of Cyclic Tetrapeptides","year":2012,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Tripeptide; Scaffold; Regioselectivity; Azide; Nucleophile; Combinatorial chemistry; Residue (chemistry); Homogeneous; Cyclic peptide; Amino acid residue; Amino acid; Stereochemistry; Peptide; Peptide sequence; Organic chemistry; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008815898,0.00007805636,0.0001036805,0.00002155814,0.00002958498,0.000006970053,0.00009210278,0.00005732079,0.0000854873],"category_scores_gemma":[0.00003707832,0.00007173122,0.0001150633,0.00006831183,0.00003586676,0.000003327155,0.00002155253,0.00002057522,0.00001462804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001408418,"about_ca_system_score_gemma":0.000005334481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004393415,"about_ca_topic_score_gemma":0.000001633506,"domain_scores_codex":[0.999472,0.00001194662,0.0001362659,0.0001472449,0.00006734874,0.000165199],"domain_scores_gemma":[0.999632,0.00002166357,0.00006673378,0.0002102687,0.00002128506,0.00004805606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001298645,0.00004480412,0.00248537,0.00001063041,0.00003245927,2.852789e-8,0.00003961619,0.000001996419,0.9910123,0.00002086867,0.005437435,0.0009014854],"study_design_scores_gemma":[0.0001614892,0.00001479613,0.001544629,0.000004284543,0.00002946188,6.72203e-7,0.00002653115,0.000008763994,0.9823271,0.000004172643,0.01578908,0.00008902266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963203,0.0003599994,0.002655853,0.0004691949,0.00003564867,0.00007377344,0.00001462248,0.000006118187,0.00006447448],"genre_scores_gemma":[0.9985076,0.00004754401,0.0007357822,0.0003078106,0.0002421608,0.0000111691,0.00009194951,0.00001544731,0.00004049292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01035165,"threshold_uncertainty_score":0.2925114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412515764952416,"score_gpt":0.2286891857178217,"score_spread":0.2145640280682976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}