{"id":"W2319061195","doi":"10.1016/j.celrep.2016.03.042","title":"CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Ministry of Science and Technology of the People's Republic of China; Cancer Research UK","keywords":"CRISPR; Subgenomic mRNA; Cas9; Biology; Indel; Genetics; Viral replication; Genome editing; DNA; Guide RNA; Virology; Computational biology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116435,0.0001131535,0.00008691316,0.00002879714,0.00005829361,0.00002336941,0.00004281339,0.00008521936,0.00002740902],"category_scores_gemma":[0.00006947447,0.0000924351,0.00003939513,0.00003613525,0.00004062573,0.000005374943,0.0000599159,0.00003426737,0.000007660004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008404487,"about_ca_system_score_gemma":0.00003129871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004675551,"about_ca_topic_score_gemma":0.000004607845,"domain_scores_codex":[0.9991221,0.00001293213,0.0002192857,0.0004168072,0.00006929618,0.0001596199],"domain_scores_gemma":[0.999275,0.000007470926,0.00009300847,0.0004961903,0.00004815975,0.00008014299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006082782,0.00001538258,0.002128062,0.00001077612,0.000007848542,0.00001911339,0.00003167507,0.00003071012,0.9925262,0.0000060205,0.001754389,0.003463783],"study_design_scores_gemma":[0.0001988257,0.00004919535,0.008056457,0.00001050731,0.00001391426,0.0001144454,0.0000206846,0.00002973396,0.9657347,0.0000931469,0.02552875,0.0001496544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722865,0.0005744112,0.02459184,0.0002158056,0.000111822,0.0001465735,0.00000524108,0.00002610797,0.002041665],"genre_scores_gemma":[0.9961902,0.0001901344,0.0008144547,0.00007297454,0.0001185352,0.00002664089,0.00006312181,0.00002119719,0.002502752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02679147,"threshold_uncertainty_score":0.3769394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00785290422592249,"score_gpt":0.2681885754275171,"score_spread":0.2603356712015946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}