{"id":"W2319061195","doi":"10.1016/j.celrep.2016.03.042","title":"CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Ministry of Science and Technology of the People's Republic of China; Cancer Research UK","keywords":"CRISPR; Subgenomic mRNA; Cas9; Biology; Indel; Genetics; Viral replication; Genome editing; DNA; Guide RNA; Virology; Computational biology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002370148,0.0004529501,0.0004389715,0.0002453157,0.0001504801,0.0005377864,0.0002885627,0.0004821137,0.001736553],"category_scores_gemma":[0.0003131295,0.0001814555,0.0002728441,0.0001270058,0.0002714296,0.0002234724,0.0003256233,0.00073025,0.0006664891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615088,"about_ca_system_score_gemma":0.0002356633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002956697,"about_ca_topic_score_gemma":0.0006234748,"domain_scores_codex":[0.9997466,0.00003437874,0.00003028802,0.00003835716,0.0001104138,0.00003996216],"domain_scores_gemma":[0.9998308,0.00004683279,0.00005149642,0.00002308239,0.00001744443,0.00003033853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023478,0.00005053614,0.0003943803,0.0001438746,0.00002055433,0.0001659338,0.00001929141,0.0005342258,0.9804371,0.001890324,0.0004833567,0.01575804],"study_design_scores_gemma":[0.00004506088,0.0002658761,0.001768265,0.00001743369,0.00002275834,0.0009633099,0.00001280956,0.002036459,0.9833787,0.0005693152,0.01090908,0.00001093542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9164325,0.01199577,0.04497089,0.0009081888,0.0003245934,0.0002288304,0.0008016552,0.001594496,0.0227431],"genre_scores_gemma":[0.9755491,0.003174995,0.01369628,0.0002583686,0.00003903798,0.00007093365,0.000281761,0.00008816611,0.006841409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001736553,"threshold_uncertainty_score":0.005809367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00785290422592249,"score_gpt":0.2681885754275171,"score_spread":0.2603356712015946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}