{"id":"W2319097181","doi":"10.1021/tx500019u","title":"Involvement of Myeloperoxidase and NADPH Oxidase in the Covalent Binding of Amodiaquine and Clozapine to Neutrophils: Implications for Drug-Induced Agranulocytosis","year":2014,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Clozapine; Myeloperoxidase; Amodiaquine; Drug; Pharmacology; Chemistry; Covalent binding; NADPH oxidase; Medicine; Biochemistry; Immunology; Enzyme; Chloroquine; Psychiatry; Schizophrenia (object-oriented programming); Inflammation; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000721616,0.00008961151,0.000191164,0.0001272313,0.00003525963,0.000006457042,0.0001714975,0.0001016182,0.000001273779],"category_scores_gemma":[0.0003667563,0.00006900395,0.00002900975,0.0002095376,0.0001847149,0.000002759226,0.0001745328,0.00009774465,2.625428e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002053006,"about_ca_system_score_gemma":0.00004084698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008009912,"about_ca_topic_score_gemma":0.000207765,"domain_scores_codex":[0.9989697,0.0001362361,0.0002375566,0.000289828,0.00009066166,0.0002759699],"domain_scores_gemma":[0.9993253,0.0002303586,0.00003960753,0.0002358535,0.00008299814,0.00008584098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001729911,0.0003845226,0.006273242,0.00007809187,0.00001629616,4.678401e-7,0.0001175311,0.00000143219,0.9843114,0.0006500017,0.0001345276,0.007859514],"study_design_scores_gemma":[0.00244167,0.0009514032,0.01291755,0.00003162768,0.000008969585,0.000002405656,0.0001675097,0.00002199629,0.9816613,0.0009363046,0.0007796349,0.00007958995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953352,0.0003858602,0.00002296025,0.003497594,0.000008787575,0.0006782188,0.00002521986,0.000001159042,0.0000449512],"genre_scores_gemma":[0.9987696,0.00026985,0.0003405714,0.0001623926,0.00002088027,0.000379629,0.00004273349,0.000008103925,0.000006194755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007779924,"threshold_uncertainty_score":0.2813899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07163424902018764,"score_gpt":0.3753867750995762,"score_spread":0.3037525260793885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}