{"id":"W2319097181","doi":"10.1021/tx500019u","title":"Involvement of Myeloperoxidase and NADPH Oxidase in the Covalent Binding of Amodiaquine and Clozapine to Neutrophils: Implications for Drug-Induced Agranulocytosis","year":2014,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Clozapine; Myeloperoxidase; Amodiaquine; Drug; Pharmacology; Chemistry; Covalent binding; NADPH oxidase; Medicine; Biochemistry; Immunology; Enzyme; Chloroquine; Psychiatry; Schizophrenia (object-oriented programming); Inflammation; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003123763,0.0005999978,0.0002801359,0.0003050443,0.0001217809,0.0003324122,0.0003530629,0.0006811864,0.0005781064],"category_scores_gemma":[0.0002961053,0.0001830829,0.0002853555,0.00009195495,0.0003875849,0.0003550799,0.0002913362,0.0004676003,0.000131479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002569533,"about_ca_system_score_gemma":0.0001304655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004416677,"about_ca_topic_score_gemma":0.0004490837,"domain_scores_codex":[0.999737,0.00007386558,0.00002333984,0.00003559867,0.00007378504,0.00005647193],"domain_scores_gemma":[0.9997532,0.00002818933,0.0001102081,0.00002195079,0.00003009726,0.00005624469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002223168,0.00003343881,0.00217925,0.00009557571,0.00001575363,0.0005933718,0.0000304905,0.00004211747,0.9941015,0.0002539878,0.00002375929,0.002408496],"study_design_scores_gemma":[0.0000574377,0.000956326,0.08904381,0.00004244446,0.0001000213,0.006277284,0.0001783028,0.002237771,0.8964858,0.0004704393,0.004131441,0.00001897475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756637,0.0146802,0.007766808,0.0005227236,0.00004097928,0.00004981338,0.00009269076,0.00007718265,0.00110594],"genre_scores_gemma":[0.9952427,0.002025822,0.001880873,0.00008318885,0.00001749228,0.00002317032,0.00006055871,0.000004436411,0.0006617897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006811864,"threshold_uncertainty_score":0.001933932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07163424902018764,"score_gpt":0.3753867750995762,"score_spread":0.3037525260793885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}