{"id":"W2319116598","doi":"10.1039/b409221j","title":"Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety","year":2004,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Canada Excellence Research Chairs, Government of Canada","keywords":"Moiety; Chemistry; Polyketide; Stereochemistry; Malonate; Biosynthesis; Antibiotics; Streptomyces; Valine; Biochemistry; Bacteria; Amino acid; Enzyme; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008543078,0.0003007224,0.000195115,0.0002259231,0.0001580802,0.0002705999,0.0001221968,0.0002087672,0.0002746122],"category_scores_gemma":[0.0001387946,0.00008891281,0.0001421007,0.0002136432,0.0001852522,0.0001449452,0.000235954,0.0003093722,0.0001505106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004067332,"about_ca_system_score_gemma":0.0003144601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007109735,"about_ca_topic_score_gemma":0.0008367546,"domain_scores_codex":[0.9999195,0.00001504719,0.000008443166,0.00002390241,0.00001834424,0.00001468235],"domain_scores_gemma":[0.9998683,0.00001309868,0.00003588861,0.00001987727,0.00001192649,0.00005095997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007826605,0.000006583617,0.0002814579,0.00002048245,0.000002288444,0.00007046629,0.000007665069,0.000116346,0.996971,0.0001186983,0.00001296448,0.002313686],"study_design_scores_gemma":[0.000006174484,0.0001422057,0.001880565,0.000004142839,0.00001099246,0.0004241547,0.00000971492,0.0003957819,0.993892,0.00003858648,0.003191548,0.000004286798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897975,0.002287688,0.00515958,0.00007057785,0.00002309627,0.00003859547,0.0004360157,0.0000555796,0.002131314],"genre_scores_gemma":[0.9901631,0.0008798309,0.007604077,0.00002266906,0.000006832026,0.000007747305,0.0004968094,0.00001233173,0.0008066905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007109735,"threshold_uncertainty_score":0.002951026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009146570894734125,"score_gpt":0.2377293427752048,"score_spread":0.2285827718804707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}