{"id":"W2319150452","doi":"10.1021/bi500317h","title":"Terminal Residue Hydrophobicity Modulates Transmembrane Helix–Helix Interactions","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Circular dichroism; Helix (gastropod); Transmembrane domain; Peptide; Protein secondary structure; Transmembrane protein; Biophysics; Dimer; Peptide sequence; Stereochemistry; Biochemistry; Amino acid; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009209518,0.0001651788,0.0001278444,0.00005810446,0.00008941702,0.0001659854,0.00007866358,0.0001516867,0.001038676],"category_scores_gemma":[0.0001740647,0.00007436841,0.00009361646,0.00005381531,0.0001742126,0.0001439162,0.0001482539,0.0002037741,0.0002265087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001089345,"about_ca_system_score_gemma":0.0000811229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002477867,"about_ca_topic_score_gemma":0.0003292503,"domain_scores_codex":[0.9999269,0.00002048441,0.000005337081,0.00001241975,0.0000148936,0.00001990987],"domain_scores_gemma":[0.999873,0.00003704112,0.00003047451,0.000009131243,0.0000123524,0.0000378642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008953443,0.000006964831,0.0002824131,0.000005850178,0.000001661627,0.00003088844,0.000006172582,0.00002763498,0.999315,0.00001712139,0.000004754582,0.0002119657],"study_design_scores_gemma":[0.00002212725,0.0004213369,0.0264335,0.000004520229,0.0000138938,0.0002857855,0.00004229511,0.001566536,0.9706391,0.00007830044,0.0004849389,0.000007761804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994341,0.000049807,0.0002408634,0.00001081748,0.000002272772,0.000002960087,0.00001961826,0.000005373275,0.0002342807],"genre_scores_gemma":[0.9996951,0.00003528333,0.0001162598,0.000008738319,0.000001316457,0.000001651502,0.00002264728,0.000002616333,0.0001164787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038676,"threshold_uncertainty_score":0.003474712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006281076246322383,"score_gpt":0.2423941478102187,"score_spread":0.2361130715638963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}