{"id":"W2319171931","doi":"10.1016/j.nbt.2014.05.2028","title":"Relationship between amino acid properties and catalytic function in bacterial flavin-containing monooxygenase using deep mutational scanning approach","year":2014,"lang":"en","type":"article","venue":"New Biotechnology","topic":"Microbial Community Ecology and Physiology","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kootenay Association for Science & Technology","funders":"","keywords":"Monooxygenase; Flavin group; Chemistry; Flavin-containing monooxygenase; Function (biology); Catalysis; Biochemistry; Combinatorial chemistry; Biology; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002668208,0.0001240549,0.000184724,0.0001245966,0.0002401296,0.00001319379,0.0001683253,0.0004208016,0.00009573493],"category_scores_gemma":[0.000163368,0.0001243664,0.00001886447,0.0002021279,0.0003484929,0.0001925176,0.0002322352,0.000417605,0.00003097804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00011198,"about_ca_system_score_gemma":0.00002133541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006359,"about_ca_topic_score_gemma":0.0009577989,"domain_scores_codex":[0.999061,0.0001683504,0.0002097944,0.0002688534,0.0000466807,0.000245297],"domain_scores_gemma":[0.9995772,0.00009428777,0.00008576929,0.0001945301,0.00000396176,0.0000442867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002091455,0.00005429102,0.4395147,0.00002262805,0.00001837186,0.000002029922,0.001047402,0.003160169,0.5419176,0.001979953,0.00006566902,0.01200804],"study_design_scores_gemma":[0.001155385,0.0003881714,0.9593893,0.00001685022,0.00004219711,0.00005269134,0.0003780814,0.01131567,0.02077785,0.005530073,0.0006084138,0.000345266],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990451,0.0000319267,0.008698136,0.0003034098,0.00006917991,0.0001464314,0.000001468828,0.00005324991,0.0002451923],"genre_scores_gemma":[0.9969127,9.84737e-7,0.002818216,0.00009805654,0.00006025049,0.000006516201,0.00006682531,0.00001011645,0.00002635188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5211397,"threshold_uncertainty_score":0.5071516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04551718091271009,"score_gpt":0.2293146719765265,"score_spread":0.1837974910638164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}