{"id":"W2319323804","doi":"10.1111/jphp.12538","title":"Investigation of the effect of food and omeprazole on the relative bioavailability of a single oral dose of 240 mg faldaprevir, a selective inhibitor of HCV NS3/4 protease, in an open-label, randomized, three-way cross-over trial in healthy participants","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Omeprazole; Cmax; Bioavailability; Dosing; Pharmacology; Medicine; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007542745,0.0001656184,0.001283549,0.0002603073,0.00003753576,0.000005660567,0.0002279289,0.00009024103,0.0001092922],"category_scores_gemma":[0.002402159,0.00008163086,0.00009304813,0.0004852617,0.001382449,0.0003638934,0.0001395341,0.000503045,1.829178e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001009271,"about_ca_system_score_gemma":0.0005043226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000345673,"about_ca_topic_score_gemma":0.0001771205,"domain_scores_codex":[0.9932017,0.004416128,0.001516029,0.0002006115,0.0004157379,0.0002498068],"domain_scores_gemma":[0.9943246,0.003479338,0.001484673,0.0001492272,0.0004089357,0.0001532592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.4148112,0.0006586589,0.1810047,0.000313181,0.0001579312,0.000002718722,0.0008784836,0.000002668643,0.3998789,0.00002080707,0.00002784526,0.002242884],"study_design_scores_gemma":[0.3962909,0.01289944,0.01489407,0.0003658612,0.000186732,0.000003050054,0.00001259643,0.0002924489,0.5745911,0.0004036342,0.00001164708,0.00004856465],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994102,0.0004648264,0.000005214762,0.0008214762,0.0001346382,0.004364325,0.00006703208,0.000001332594,0.00003918322],"genre_scores_gemma":[0.9994782,0.0002217451,0.00004353906,0.0000902676,0.00005733353,0.00009262352,5.91725e-7,0.00001189099,0.000003865098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1747121,"threshold_uncertainty_score":0.509369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.147871841897321,"score_gpt":0.4492290956127896,"score_spread":0.3013572537154685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}