{"id":"W2319323804","doi":"10.1111/jphp.12538","title":"Investigation of the effect of food and omeprazole on the relative bioavailability of a single oral dose of 240 mg faldaprevir, a selective inhibitor of HCV NS3/4 protease, in an open-label, randomized, three-way cross-over trial in healthy participants","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Omeprazole; Cmax; Bioavailability; Dosing; Pharmacology; Medicine; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002316163,0.0009574183,0.001507759,0.0003112487,0.0004849935,0.0005745274,0.000555414,0.001558423,0.001737306],"category_scores_gemma":[0.003004004,0.0008360389,0.0009274057,0.0002406706,0.001054127,0.0009774189,0.000413842,0.001589185,0.0003019791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004175412,"about_ca_system_score_gemma":0.000647286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005342484,"about_ca_topic_score_gemma":0.0009104694,"domain_scores_codex":[0.9988105,0.0005895986,0.00008687386,0.0002508697,0.0001588574,0.0001032809],"domain_scores_gemma":[0.9976065,0.0008903864,0.0006589894,0.0002103891,0.0001846524,0.0004490699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8860046,0.040035,0.003490158,0.0004269012,0.0007175315,0.00006821237,0.0001946859,0.0003174004,0.04543582,0.00003798843,0.0001431349,0.02312859],"study_design_scores_gemma":[0.09157556,0.8821366,0.01621802,0.00001243435,0.0004818022,0.00006060944,0.00004586811,0.000561637,0.008465546,0.00003375348,0.0003836605,0.00002446831],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988467,0.0003898213,0.0001949059,0.00004255681,0.00004320806,0.0002907473,0.00005595684,0.00001330362,0.0001227109],"genre_scores_gemma":[0.9973858,0.0002916399,0.001092421,0.0001220029,0.0001134239,0.0003454741,0.00009032516,0.000009224163,0.0005496888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002316163,"threshold_uncertainty_score":0.01224917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.147871841897321,"score_gpt":0.4492290956127896,"score_spread":0.3013572537154685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}