{"id":"W2319368514","doi":"10.1186/s12859-016-0997-6","title":"Unaccounted uncertainty from qPCR efficiency estimates entails uncontrolled false positive rates","year":2016,"lang":"en","type":"article","venue":"BMC Bioinformatics","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Danish Agency for Science and Higher Education; Forsknings- og Innovationsstyrelsen; Stem Cell Network","keywords":"Statistics; DNA microarray; Computational biology; Biology; Computer science; Econometrics; Genetics; Mathematics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.05256739,0.002423937,0.002709393,0.001923621,0.001497095,0.0047101,0.003863048,0.003004479,0.002791164],"category_scores_gemma":[0.1330951,0.001663741,0.002934021,0.002143299,0.005313437,0.00300952,0.003735592,0.004940376,0.001842727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002487628,"about_ca_system_score_gemma":0.00255069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002230215,"about_ca_topic_score_gemma":0.002654096,"domain_scores_codex":[0.9498824,0.01774045,0.003345868,0.01122382,0.01676293,0.001044581],"domain_scores_gemma":[0.8434366,0.1157563,0.01137983,0.01817761,0.01077082,0.0004787693],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001135565,0.000356951,0.07033739,0.006746737,0.001785652,0.001387445,0.003271591,0.1000295,0.2853009,0.1197605,0.01187791,0.3980097],"study_design_scores_gemma":[0.0001122562,0.0007591649,0.02847597,0.001523413,0.0009237657,0.002665628,0.0004138666,0.2387095,0.477104,0.1806139,0.06798982,0.0007087054],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.008645574,0.001258196,0.9856514,0.0004510631,0.0003319474,0.0001320017,0.0003141823,0.001371847,0.001843755],"genre_scores_gemma":[0.3919625,0.001755065,0.5963237,0.001678503,0.0003526595,0.001390612,0.00117611,0.002000913,0.003359998],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.9474326,"threshold_uncertainty_score":0.2780063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00815022176829765,"score_gpt":0.2639605235602022,"score_spread":0.2558103017919046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}