{"id":"W2319556652","doi":"10.1021/bm200804j","title":"pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery","year":2011,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":259,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Micelle; Nanocarriers; Doxorubicin; Chemistry; Copolymer; Cytotoxicity; Drug delivery; Biophysics; Polymerization; Nuclear chemistry; Combinatorial chemistry; Ethylene glycol; Aqueous solution; Organic chemistry; In vitro; Biochemistry; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176285,0.0004138204,0.0001863343,0.0001368283,0.00007406536,0.0001763854,0.0001752336,0.0003318103,0.0006104378],"category_scores_gemma":[0.0001314825,0.0001660226,0.000152509,0.0000625595,0.0001370633,0.0004207635,0.0002238942,0.0003819948,0.0003275097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364528,"about_ca_system_score_gemma":0.0001304945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001279258,"about_ca_topic_score_gemma":0.0002479916,"domain_scores_codex":[0.9998926,0.00001808182,0.000009712472,0.00003234173,0.00003193785,0.00001531783],"domain_scores_gemma":[0.9999434,0.000009263934,0.00002166802,0.000003776619,0.00001180277,0.00001014429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001756505,0.000007529789,0.00002261259,0.00002685424,0.000001820618,0.00001754088,0.00000650331,0.00006243198,0.9977831,0.000136613,0.00002676295,0.001890661],"study_design_scores_gemma":[0.00001262143,0.0001079836,0.0001432297,0.000002925688,0.000006127382,0.0001367321,0.000003032357,0.001077096,0.9955304,0.00003650596,0.002939235,0.000004080202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8606015,0.01521977,0.1160137,0.0005842038,0.0002105105,0.0002042947,0.0001624838,0.0004945561,0.006509053],"genre_scores_gemma":[0.956319,0.003964304,0.03358049,0.0001713587,0.00006398696,0.00009309799,0.0001236594,0.00004388036,0.005640114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006104378,"threshold_uncertainty_score":0.002042115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723426045059966,"score_gpt":0.2213886192501804,"score_spread":0.2041543587995807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}