{"id":"W2319556652","doi":"10.1021/bm200804j","title":"pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery","year":2011,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":259,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Micelle; Nanocarriers; Doxorubicin; Chemistry; Copolymer; Cytotoxicity; Drug delivery; Biophysics; Polymerization; Nuclear chemistry; Combinatorial chemistry; Ethylene glycol; Aqueous solution; Organic chemistry; In vitro; Biochemistry; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002737182,0.0002202357,0.0002276283,0.0001117832,0.0001998431,0.00006361133,0.0001125718,0.00009298271,0.00009368332],"category_scores_gemma":[0.00004117899,0.0002117572,0.00006895111,0.0001627261,0.0003668063,0.0001977368,0.00008338922,0.00004575924,0.0001161628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003985582,"about_ca_system_score_gemma":0.00005193152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002962599,"about_ca_topic_score_gemma":0.00001339545,"domain_scores_codex":[0.9985214,0.0001100587,0.0002969338,0.0004983289,0.0001663058,0.00040695],"domain_scores_gemma":[0.9992645,0.00007681669,0.00014117,0.0002559686,0.0001263437,0.0001351977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002657967,0.0001194657,0.00001687859,0.00003099228,0.00001788859,0.00006894689,0.000829407,9.860703e-7,0.9957848,0.0006163716,0.0004425185,0.001805903],"study_design_scores_gemma":[0.0006214685,0.0002300333,0.0001583233,0.00003071856,0.00006611949,0.0001437928,0.000710934,0.0001742424,0.9970022,0.0003286072,0.0002581364,0.0002753818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99538,0.001508537,0.00170714,0.00009711494,0.0004667643,0.0004238544,0.00006068331,0.0001384306,0.0002175176],"genre_scores_gemma":[0.9904522,0.00005825697,0.00906879,0.0000823225,0.0001124669,0.00004333017,0.00001644158,0.00003469323,0.000131544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007361649,"threshold_uncertainty_score":0.8635208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723426045059966,"score_gpt":0.2213886192501804,"score_spread":0.2041543587995807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}