{"id":"W2319557481","doi":"10.1021/bi401125v","title":"Cholesterol-Mediated Conformational Changes in the Steroidogenic Acute Regulatory Protein Are Essential for Steroidogenesis","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Steroidogenic acute regulatory protein; Cholesterol; Sterol; Chemistry; Amino acid; Cholesterol side-chain cleavage enzyme; Biochemistry; Proteolysis; Metabolism; Cytochrome P450; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002465902,0.0002968037,0.000408627,0.0001329036,0.0002383039,0.0002468659,0.0001822255,0.0002417365,0.0008100168],"category_scores_gemma":[0.000402557,0.000132345,0.0003123397,0.0001565756,0.0002931567,0.0002202495,0.0001999408,0.0004641069,0.0005311227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003480572,"about_ca_system_score_gemma":0.0002204628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006417561,"about_ca_topic_score_gemma":0.0008768757,"domain_scores_codex":[0.999788,0.00004112539,0.0000173225,0.00003965111,0.00007406227,0.00003995905],"domain_scores_gemma":[0.9997047,0.000068432,0.00008647134,0.00002990594,0.00006182741,0.00004858668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001284231,0.00001254807,0.0008420291,0.00005271007,0.000007392263,0.00008750558,0.00002211762,0.00005985481,0.9974268,0.0001041301,0.00003595557,0.001220593],"study_design_scores_gemma":[0.00002525031,0.0002097738,0.03381511,0.00001253414,0.00002518422,0.0005598654,0.00008447328,0.002117116,0.9596803,0.0003094938,0.003141316,0.00001960564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909816,0.003230143,0.004585605,0.0002048536,0.00004656922,0.00002497194,0.0002619423,0.00007928894,0.0005850503],"genre_scores_gemma":[0.9947744,0.001137842,0.002423667,0.0000823028,0.00002001836,0.00002195029,0.0004980521,0.00001769144,0.00102408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008100168,"threshold_uncertainty_score":0.002709806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339773974588864,"score_gpt":0.2457953115975002,"score_spread":0.2323975718516116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}