{"id":"W2319597223","doi":"10.1021/jm401432c","title":"Integrated Strategies for Identifying Leads That Target the NS3 Helicase of the Hepatitis C Virus","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Helicase; In silico; Drug discovery; Hepatitis C virus; Computational biology; Chemistry; NS3; Hepacivirus; Drug; Virus; Virology; Biochemistry; Biology; RNA; Pharmacology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009555257,0.001191298,0.001437638,0.001569274,0.0004582629,0.001662561,0.0009139308,0.0006051646,0.003957005],"category_scores_gemma":[0.001023064,0.0007435282,0.0008429833,0.001150869,0.0004970387,0.001098006,0.001491941,0.001660295,0.001110211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007514123,"about_ca_system_score_gemma":0.001273714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006525074,"about_ca_topic_score_gemma":0.002064552,"domain_scores_codex":[0.9994063,0.0001087837,0.0000534076,0.00008886851,0.0002558985,0.00008675557],"domain_scores_gemma":[0.9997008,0.00005700888,0.00007713073,0.00006099937,0.0000634434,0.00004072443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007280772,0.001134968,0.001260249,0.0005499162,0.0001791059,0.0002599934,0.00008794419,0.01074274,0.8412753,0.005386762,0.0009110386,0.137484],"study_design_scores_gemma":[0.0007703598,0.006727565,0.003666191,0.0001044983,0.0005999834,0.001470175,0.0001912409,0.03441061,0.9097567,0.006484262,0.03570372,0.0001147666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5243775,0.02835159,0.4063741,0.002351634,0.0003149227,0.005310694,0.003439775,0.00307871,0.02640105],"genre_scores_gemma":[0.6073529,0.01558521,0.3644883,0.0007309226,0.00008247238,0.001224073,0.003271023,0.0001556969,0.007109442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003957005,"threshold_uncertainty_score":0.01323748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0561967875297628,"score_gpt":0.348740554289053,"score_spread":0.2925437667592902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}