{"id":"W2319616587","doi":"10.1016/j.ccell.2016.03.006","title":"Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma","year":2016,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health; Dr. Mildred Scheel Stiftung für Krebsforschung; Center for Cancer Research","keywords":"BCL10; IκB kinase; Ubiquitin; Ubiquitin ligase; Cancer research; breakpoint cluster region; Diffuse large B-cell lymphoma; Lymphoma; Cell biology; B-cell receptor; Biology; B cell; NF-κB; Signal transduction; Receptor; Genetics; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189921,0.0001445771,0.0001232526,0.00001211438,0.00009718386,0.000009258642,0.0001451908,0.00009048931,0.000056105],"category_scores_gemma":[0.00001729625,0.00008233847,0.0001120859,0.00003296508,0.00004148257,0.000004132593,0.00002966442,0.00001190603,0.000005962635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006918491,"about_ca_system_score_gemma":0.0001016812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004554061,"about_ca_topic_score_gemma":0.00002587215,"domain_scores_codex":[0.9992009,0.0000280764,0.0001760176,0.0002518768,0.00008241129,0.0002607335],"domain_scores_gemma":[0.9994231,0.00002938726,0.0001431211,0.0002641305,0.00009387526,0.0000463866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001149248,0.0005014741,0.0001066493,0.0000814403,0.00001874632,3.300836e-7,0.0001695675,0.000002371919,0.9850773,0.0000271167,0.0003519187,0.01354816],"study_design_scores_gemma":[0.004601867,0.0006137473,0.00005360217,0.00002579903,0.0000233134,2.20087e-7,0.00006347523,0.0001175515,0.9029899,0.00003347202,0.09135681,0.0001202727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775747,0.006189774,0.01291066,0.0001880299,0.0001514414,0.001799655,0.000253882,0.00001136056,0.0009204675],"genre_scores_gemma":[0.991803,0.001166558,0.0004005971,0.00006129908,0.000360682,0.001355189,0.00003104706,0.00002830831,0.004793325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09100489,"threshold_uncertainty_score":0.3357665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147475244640959,"score_gpt":0.2466162514576888,"score_spread":0.2351414990112792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}