{"id":"W2319616587","doi":"10.1016/j.ccell.2016.03.006","title":"Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma","year":2016,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health; Dr. Mildred Scheel Stiftung für Krebsforschung; Center for Cancer Research","keywords":"BCL10; IκB kinase; Ubiquitin; Ubiquitin ligase; Cancer research; breakpoint cluster region; Diffuse large B-cell lymphoma; Lymphoma; Cell biology; B-cell receptor; Biology; B cell; NF-κB; Signal transduction; Receptor; Genetics; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002206556,0.0002388009,0.0004532686,0.0004011958,0.0002623721,0.0004510431,0.0002421474,0.0002933286,0.001083611],"category_scores_gemma":[0.00008655336,0.00008389421,0.0003425004,0.0003491023,0.0002368486,0.0002120634,0.0002499938,0.0006612398,0.0003514689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003953531,"about_ca_system_score_gemma":0.0002270159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004187524,"about_ca_topic_score_gemma":0.001507036,"domain_scores_codex":[0.99991,0.00001880829,0.000006624874,0.000009983952,0.00002442689,0.00003010875],"domain_scores_gemma":[0.9999679,0.000004918424,0.000007907503,0.000004738151,0.000006156391,0.000008384683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003911045,0.001123652,0.001869068,0.001410576,0.0002114508,0.001082616,0.00008968875,0.001812251,0.5824689,0.003185304,0.006382622,0.3964529],"study_design_scores_gemma":[0.002171005,0.008467533,0.01965515,0.0002472471,0.0006060089,0.009169795,0.0001849648,0.004648353,0.7780231,0.003004639,0.1737373,0.00008491311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5641951,0.40856,0.012036,0.00254216,0.0005181931,0.0002319351,0.0003444572,0.0003929711,0.01117916],"genre_scores_gemma":[0.9427499,0.05062397,0.00238918,0.0003221854,0.00008188127,0.00005379521,0.0001999234,0.00002031042,0.003558871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083611,"threshold_uncertainty_score":0.003625035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147475244640959,"score_gpt":0.2466162514576888,"score_spread":0.2351414990112792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}