{"id":"W2319653676","doi":"10.1021/bi300298v","title":"Type IV Secretion System Core Component VirB8 from <i>Brucella</i> Binds to the Globular Domain of VirB5 and to a Periplasmic Domain of VirB6","year":2012,"lang":"en","type":"article","venue":"Biochemistry","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McMaster University; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Periplasmic space; Förster resonance energy transfer; Phage display; Secretion; Function (biology); Protein–protein interaction; Cell biology; Computational biology; Domain (mathematical analysis); Biology; Chemistry; Biophysics; Peptide; Biochemistry; Physics; Gene; Escherichia coli; Fluorescence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002257276,0.0002051755,0.0002581666,0.0000299609,0.00005592194,0.00001185805,0.0003040818,0.0003800862,0.00001295222],"category_scores_gemma":[0.0000287882,0.0001663626,0.00006120925,0.0001506256,0.0001322824,0.000001824867,0.0003365612,0.00008646402,0.000008359877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002776312,"about_ca_system_score_gemma":0.00004538508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006811708,"about_ca_topic_score_gemma":0.000009441291,"domain_scores_codex":[0.9988823,0.00003984685,0.0003195185,0.0003355976,0.0001484228,0.0002743268],"domain_scores_gemma":[0.9990215,0.00001104056,0.0001480018,0.0005790285,0.0000841737,0.0001562382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002657161,0.00005522958,0.001073157,0.00007318163,0.00005808904,7.385082e-7,0.000092394,0.000004348259,0.9973289,0.00007618747,0.0006959348,0.0002761341],"study_design_scores_gemma":[0.0003539436,0.0003452501,0.001379023,0.00006229203,0.00003016975,0.00002035351,0.0004232616,0.00002174225,0.9778987,0.00001599619,0.01924948,0.000199788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997159,0.001305565,0.0003015213,0.0002447022,0.0002801148,0.0002599385,0.0002462494,0.00001217851,0.0001907384],"genre_scores_gemma":[0.9971937,0.00006957778,0.002041432,0.0001232159,0.0003072915,0.00001524841,0.0001782918,0.00002186358,0.00004937631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01943019,"threshold_uncertainty_score":0.6784071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006972051864233181,"score_gpt":0.2109042602814785,"score_spread":0.2039322084172453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}