{"id":"W2319740689","doi":"10.1158/1535-7163.targ-13-c293","title":"Abstract C293: Irinotecan sucrosofate liposome injection, MM-398, demonstrates superior activity and control of hypoxia as measured through longitudinal imaging using [18F]FAZA PET compared to free irinotecan in a colon adenocarcinoma xenograft model.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Irinotecan; Hypoxia (environmental); Tumor hypoxia; Pharmacokinetics; Medicine; Camptothecin; Colorectal cancer; Pharmacology; Nuclear medicine; Internal medicine; Chemistry; Cancer; Radiation therapy; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000793715,0.0003000883,0.0002595561,0.0001967221,0.0001273001,0.0002118181,0.0001820824,0.0003653351,0.002616857],"category_scores_gemma":[0.00009412579,0.00009239029,0.0001535214,0.0001634488,0.0002129811,0.0002536894,0.00009153379,0.000498219,0.0005782146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004895595,"about_ca_system_score_gemma":0.0003180945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001950865,"about_ca_topic_score_gemma":0.001105311,"domain_scores_codex":[0.9998771,0.00001097421,0.000009393041,0.00003091439,0.00004701454,0.00002463537],"domain_scores_gemma":[0.9999291,0.00001042898,0.00002453279,0.000006666049,0.000009897747,0.00001940041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002629805,0.000056814,0.00008240005,0.00002264634,0.000003786619,0.0000453306,0.000006984174,0.0000978328,0.9980779,0.00006973196,0.00009467496,0.001178912],"study_design_scores_gemma":[0.00001719422,0.0003728613,0.000774259,0.000001543016,0.000004665468,0.0001348696,0.000006544939,0.0006526092,0.9970591,0.00001293081,0.0009611832,0.00000228305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945141,0.0006170368,0.001955666,0.0001439329,0.00003225359,0.00004013971,0.0005326335,0.000121039,0.002043193],"genre_scores_gemma":[0.9934767,0.0003205104,0.00176858,0.00004168681,0.000007541882,0.00003654726,0.000737434,0.00003455964,0.003576432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002616857,"threshold_uncertainty_score":0.008754253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02623049457779287,"score_gpt":0.2812783448882339,"score_spread":0.255047850310441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}