{"id":"W2319740689","doi":"10.1158/1535-7163.targ-13-c293","title":"Abstract C293: Irinotecan sucrosofate liposome injection, MM-398, demonstrates superior activity and control of hypoxia as measured through longitudinal imaging using [18F]FAZA PET compared to free irinotecan in a colon adenocarcinoma xenograft model.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Irinotecan; Hypoxia (environmental); Tumor hypoxia; Pharmacokinetics; Medicine; Camptothecin; Colorectal cancer; Pharmacology; Nuclear medicine; Internal medicine; Chemistry; Cancer; Radiation therapy; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002031966,0.0004850462,0.000632518,0.0001566705,0.0001521991,0.000113906,0.0003797677,0.000165621,0.00002311656],"category_scores_gemma":[0.00003213184,0.0005207348,0.0001811721,0.000314559,0.0002964603,0.00005083252,0.0001582789,0.0003031964,0.000001829479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001307002,"about_ca_system_score_gemma":0.0004490933,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009190099,"about_ca_topic_score_gemma":0.002004269,"domain_scores_codex":[0.9975688,0.0001276167,0.0005071088,0.0007619605,0.0003627756,0.000671756],"domain_scores_gemma":[0.998515,0.00002024512,0.0002317718,0.0006783115,0.0003561287,0.0001985231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005118494,0.0001771601,0.016657,0.00006574301,0.0002304435,0.00001187583,0.0003397017,0.01130654,0.9668314,0.00001507152,0.00001987857,0.003833354],"study_design_scores_gemma":[0.004310656,0.0004677977,0.1039202,0.0001398396,0.0003585904,0.0001679696,0.0002280247,0.0151708,0.8726126,0.0005006386,0.00110057,0.001022346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756223,0.01216653,0.01027982,0.0004250495,0.0003248618,0.000959725,0.0001432433,0.00002844729,0.00005002486],"genre_scores_gemma":[0.9968848,0.0005698533,0.0012729,0.0007932658,0.0002046715,0.0001551457,0.00001587895,0.00008582405,0.00001761003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0942188,"threshold_uncertainty_score":0.9997244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02623049457779287,"score_gpt":0.2812783448882339,"score_spread":0.255047850310441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}