{"id":"W2319796016","doi":"10.1158/1538-7445.am10-4291","title":"Abstract 4291: Imetelstat, a telomerase inhibitor in phase I trials in solid tumor and hematological malignancies, has broad activity against multiple types of cancer stem cells","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Telomerase; Cancer research; Telomere; Cancer; Cancer stem cell; Clonogenic assay; Metastasis; Cancer cell; Immunology; Biology; Stem cell; Medicine; Cell; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001050118,0.0009019137,0.001396515,0.0008615161,0.0004450183,0.0009230597,0.000684779,0.001100037,0.00813546],"category_scores_gemma":[0.0003863493,0.0002925294,0.0006661139,0.0007338778,0.0002788581,0.0005479844,0.0002973234,0.00281802,0.002116275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004778445,"about_ca_system_score_gemma":0.001035664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006508807,"about_ca_topic_score_gemma":0.001973093,"domain_scores_codex":[0.9996519,0.0001050027,0.00002868194,0.00004297333,0.00007859252,0.00009270872],"domain_scores_gemma":[0.9997055,0.00004767324,0.00004533836,0.00001929526,0.00003409985,0.0001481998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04757322,0.02659521,0.005503071,0.002321118,0.0009965315,0.0005450631,0.0002130174,0.003669718,0.3358277,0.002588145,0.03963842,0.5345289],"study_design_scores_gemma":[0.1407216,0.3676247,0.05579597,0.0005278343,0.001912269,0.003297718,0.0001918277,0.01000701,0.2425558,0.001611974,0.1756027,0.0001506443],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8358962,0.05975741,0.009533755,0.00376074,0.001402027,0.00655702,0.01610189,0.001884218,0.06510667],"genre_scores_gemma":[0.8915447,0.02440383,0.01169757,0.004217126,0.0006585166,0.004226593,0.02433822,0.000297035,0.03861646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00813546,"threshold_uncertainty_score":0.02721584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1038440066895435,"score_gpt":0.4360111154237619,"score_spread":0.3321671087342184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}