{"id":"W2319908039","doi":"10.1038/sj.leu.2402722","title":"PML a target of translocations in APL is a regulator of cellular senescence","year":2002,"lang":"en","type":"review","venue":"Leukemia","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Regulator; Senescence; Chromosomal translocation; Cellular senescence; Biology; Master regulator; Cell biology; Genetics; Cancer research; Computational biology; Transcription factor; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001943976,0.0003822492,0.001100627,0.0001528055,0.00002591905,0.000007611833,0.0005672257,0.0007071025,0.00007542529],"category_scores_gemma":[0.00006408698,0.000355024,0.0004805701,0.0004594617,0.0001920773,0.000004049005,0.00007608054,0.0002595346,0.00001297191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001056455,"about_ca_system_score_gemma":0.0009643578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003271898,"about_ca_topic_score_gemma":0.000004348702,"domain_scores_codex":[0.9978927,0.0001217094,0.0009257164,0.0005489917,0.0002272611,0.0002836614],"domain_scores_gemma":[0.9985043,0.00002744432,0.0004934499,0.0007916549,0.0001136101,0.00006947067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008079459,0.0006538585,0.0003504799,0.1653212,0.0009012331,0.00006908159,0.001201843,0.00009340745,0.1556328,0.0005844421,0.006379719,0.6687312],"study_design_scores_gemma":[0.0003336358,0.0001043555,0.000003356547,0.004137994,0.0002201467,0.00002285524,0.0000224273,0.0000426615,0.1115472,0.00007104615,0.883078,0.0004162776],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001164835,0.9954001,0.001752612,0.000006756127,0.0000885874,0.0004153175,0.00009654703,0.000007260509,0.001067997],"genre_scores_gemma":[0.009055706,0.9879649,0.00106776,0.00002220607,0.0001205184,0.00007088182,0.0002675375,0.00006042965,0.001370067],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8766983,"threshold_uncertainty_score":0.9998901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205543791030389,"score_gpt":0.2750034512299216,"score_spread":0.2544490721268827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}