{"id":"W2319973112","doi":"10.1097/hjh.0000000000000202","title":"Missing heritability or need for reality check of clinical utility in genomic testing?","year":2014,"lang":"en","type":"letter","venue":"Journal of Hypertension","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Missing heritability problem; Heritability; Reality check; Computational biology; Genetics; Test (biology); Genotype; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.25941,0.0009754536,0.004655992,0.002876701,0.001934443,0.007923209,0.005979094,0.007728627,0.008937431],"category_scores_gemma":[0.6052534,0.0009032045,0.00134496,0.002974123,0.01737121,0.01809376,0.00704335,0.01290977,0.001716218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004307375,"about_ca_system_score_gemma":0.006956239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005580164,"about_ca_topic_score_gemma":0.003913756,"domain_scores_codex":[0.8187717,0.1324285,0.01112182,0.01400488,0.02191986,0.001753164],"domain_scores_gemma":[0.3005034,0.6262281,0.01287243,0.02756033,0.02851017,0.004325667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001920103,0.0002024293,0.06382164,0.005617657,0.001922088,0.002003991,0.006987034,0.001921986,0.0007854445,0.1622415,0.1498722,0.6027039],"study_design_scores_gemma":[0.0006712229,0.000932651,0.02982601,0.01757399,0.001355018,0.004336835,0.00452549,0.00799773,0.001110534,0.7667884,0.1643911,0.0004909586],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01402834,0.08401322,0.06734391,0.8127045,0.01078179,0.0002464885,0.001401779,0.0006126216,0.008867358],"genre_scores_gemma":[0.5613492,0.04463959,0.1047913,0.2528364,0.03214884,0.0008208017,0.001228282,0.0005931813,0.001592462],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.25941,"threshold_uncertainty_score":0.9132793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1488409573231707,"score_gpt":0.3458451980464406,"score_spread":0.1970042407232699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}