{"id":"W2319985164","doi":"10.1021/bi500349e","title":"Enzymatic and Structural Characterization of rTSγ Provides Insights into the Function of rTSβ","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; National Institute of General Medical Sciences; Wellcome; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Thymidylate synthase; Gene isoform; Dehydratase; Gene; Enzyme; Function (biology); Biology; DNA; Transferase; Biochemistry; Genetics; Molecular biology; Chemistry; Fluorouracil; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009522272,0.0000996117,0.0001098065,0.00001555736,0.00004494161,0.000009690124,0.0001344645,0.0001296362,0.000006738168],"category_scores_gemma":[0.0001232036,0.00006923142,0.00004700293,0.00006540852,0.0002216721,0.000002969648,0.0001136972,0.00006248184,4.685084e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004293399,"about_ca_system_score_gemma":0.00003346612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001066957,"about_ca_topic_score_gemma":0.000001518199,"domain_scores_codex":[0.9993445,0.0000373475,0.0001826002,0.0001992965,0.0001345436,0.0001017514],"domain_scores_gemma":[0.9994619,0.0000111631,0.0001072624,0.0002745466,0.0000995779,0.00004550547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005870352,0.00001393227,0.0004212162,0.0002176486,0.00002484574,7.314753e-8,0.00005708143,3.749427e-7,0.9945057,0.0000682079,0.00003320173,0.004599032],"study_design_scores_gemma":[0.000191454,0.0001126246,0.002902798,0.00002653646,0.00001532081,0.000002443557,0.00003113003,0.0001669193,0.9951543,0.0002031656,0.001113908,0.00007944078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983048,0.0005900099,0.0006866207,0.00009161529,0.00003017541,0.0001058991,0.000003174102,0.000004159428,0.0001835508],"genre_scores_gemma":[0.9993575,0.00007003366,0.00008590831,0.00005764708,0.00009942331,0.00001059157,0.0001426214,0.000009382732,0.0001669063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004519591,"threshold_uncertainty_score":0.2823175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004618009650334282,"score_gpt":0.2190998229201953,"score_spread":0.214481813269861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}