{"id":"W2319985164","doi":"10.1021/bi500349e","title":"Enzymatic and Structural Characterization of rTSγ Provides Insights into the Function of rTSβ","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; National Institute of General Medical Sciences; Wellcome; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Thymidylate synthase; Gene isoform; Dehydratase; Gene; Enzyme; Function (biology); Biology; DNA; Transferase; Biochemistry; Genetics; Molecular biology; Chemistry; Fluorouracil; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002085897,0.0005996096,0.0002816724,0.0002952652,0.0001677768,0.0004035375,0.0003425102,0.0003422554,0.001327164],"category_scores_gemma":[0.0003738099,0.0001805311,0.0006596828,0.0003280969,0.0002346933,0.0002871381,0.0002106608,0.0006962118,0.001038957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003822733,"about_ca_system_score_gemma":0.0003798397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00195823,"about_ca_topic_score_gemma":0.001061522,"domain_scores_codex":[0.999915,0.00001165089,0.000007970005,0.00002153172,0.00002605609,0.00001769559],"domain_scores_gemma":[0.9998135,0.00002721869,0.0000392915,0.00002314529,0.00004359841,0.00005322399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000171402,0.00001864423,0.002128843,0.00008114269,0.00001582193,0.000502301,0.00009640758,0.0006173096,0.9918875,0.000641815,0.0001666997,0.003672105],"study_design_scores_gemma":[0.00004700712,0.0002222189,0.02162504,0.0000357773,0.00008055561,0.003288015,0.0002225703,0.004182503,0.9373302,0.0006770272,0.0322564,0.00003256945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842725,0.003494662,0.007456292,0.0002757986,0.00003033269,0.00002373959,0.001499425,0.00004581742,0.002901498],"genre_scores_gemma":[0.973524,0.003845163,0.01049619,0.0001117526,0.00004353344,0.00002170291,0.007871129,0.0000572101,0.004029222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00195823,"threshold_uncertainty_score":0.004439771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004618009650334282,"score_gpt":0.2190998229201953,"score_spread":0.214481813269861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}