{"id":"W2319994857","doi":"10.1038/sj.gt.3301482","title":"Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs","year":2001,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"CpG site; Biology; DNA methylation; DNA; Immune system; Molecular biology; Plasmid; Methylated DNA immunoprecipitation; Gene; Biochemistry; Gene expression; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002737514,0.000365924,0.0002527512,0.0002483752,0.0001283634,0.000285519,0.0003030699,0.0002770754,0.001777748],"category_scores_gemma":[0.000274333,0.0001672539,0.0001993596,0.0001184552,0.0001649204,0.0001712602,0.0001914481,0.000538579,0.0003084716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002634633,"about_ca_system_score_gemma":0.000199855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003134742,"about_ca_topic_score_gemma":0.0006456501,"domain_scores_codex":[0.9999193,0.00001715034,0.00000416896,0.0000122077,0.00002389,0.00002333388],"domain_scores_gemma":[0.9999104,0.00002929417,0.00001756579,0.000007821302,0.0000164053,0.00001850491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003513,0.00004395894,0.0001742973,0.00004778775,0.000009666586,0.00003730686,0.00001034134,0.0003501821,0.9902042,0.0006999274,0.00006253601,0.00800853],"study_design_scores_gemma":[0.00002342868,0.0003327822,0.0005157244,0.000005029224,0.00001774137,0.00008526722,0.000005194127,0.001099738,0.995042,0.0001158664,0.002753748,0.000003391002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527179,0.01249459,0.02526664,0.0002557583,0.0001246718,0.0001804351,0.0003280201,0.0001609218,0.008471036],"genre_scores_gemma":[0.9829509,0.003004394,0.008340707,0.0001105433,0.00003303843,0.00007762103,0.0003553768,0.00002581562,0.005101609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001777748,"threshold_uncertainty_score":0.005947113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00990124411316648,"score_gpt":0.2411025728176927,"score_spread":0.2312013287045262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}