{"id":"W2320020197","doi":"10.1158/1538-7445.am2013-907","title":"Abstract 907: Efficacy of SAR302503, a JAK2 inhibitor, in primary human acute myeloid leukemia xenografts.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; BC Cancer Agency; Ontario Institute for Cancer Research","funders":"","keywords":"Medicine; Myeloid leukemia; Ruxolitinib; Transplantation; Leukemia; Myeloid; Stem cell; Bone marrow; Cancer research; Janus kinase 2; Myeloproliferative Disorders; Internal medicine; Pharmacology; Myelofibrosis; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294452,0.0005936943,0.0005664685,0.0002552686,0.0001556859,0.0002740975,0.000296477,0.0003412845,0.002433712],"category_scores_gemma":[0.0001027742,0.0001602665,0.0003875081,0.0002065432,0.0001802659,0.0001808868,0.0001247343,0.001060717,0.0009036039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003593925,"about_ca_system_score_gemma":0.0003372983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002120378,"about_ca_topic_score_gemma":0.002432402,"domain_scores_codex":[0.9998242,0.00004152192,0.00001427022,0.00002743683,0.00004294448,0.0000496848],"domain_scores_gemma":[0.9998599,0.00003061609,0.00002321891,0.00001986676,0.00001591497,0.00005039938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001520608,0.001075208,0.0002875958,0.00007383642,0.00002064335,0.00007380783,0.00002961273,0.0004123,0.9921887,0.000112602,0.0008490321,0.003356092],"study_design_scores_gemma":[0.0005227216,0.01488722,0.007879466,0.00001227189,0.00005336094,0.0004101085,0.00003424528,0.002892782,0.969995,0.00004734749,0.003256411,0.000009137768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905348,0.001695644,0.001140424,0.0001625266,0.0001049719,0.0001896562,0.002654374,0.0002497255,0.003267911],"genre_scores_gemma":[0.9893134,0.0009935026,0.001470187,0.00006893293,0.00001749943,0.0001554318,0.004450258,0.00004464005,0.003486131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002433712,"threshold_uncertainty_score":0.008141577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05848348975548139,"score_gpt":0.3956894276361967,"score_spread":0.3372059378807153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}