{"id":"W2320044375","doi":"10.1038/ncomms10618","title":"Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Vetenskapsrådet; Howard Hughes Medical Institute","keywords":"Virology; Antibody; Transgene; Genetically modified mouse; Human immunodeficiency virus (HIV); Neutralizing antibody; Biology; Virus; Gene; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002018145,0.0001699118,0.0002798454,0.0001947965,0.0001810241,0.000008973223,0.001062337,0.0003952803,0.0001329377],"category_scores_gemma":[0.00007511989,0.000121691,0.0001381015,0.0002375256,0.0004229297,0.0001144731,0.0001754132,0.000746805,0.0003204093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007977396,"about_ca_system_score_gemma":0.00007930711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008366273,"about_ca_topic_score_gemma":0.000362982,"domain_scores_codex":[0.9985657,0.0004343754,0.000350032,0.0002333526,0.00005231898,0.0003641629],"domain_scores_gemma":[0.9978743,0.0006198491,0.0001124806,0.001261613,0.0001009695,0.00003078866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002144448,0.000716179,0.004784411,0.00001440237,0.0001693313,0.000001100985,0.0008131724,0.000002928853,0.9859541,0.002833101,0.001169214,0.003327596],"study_design_scores_gemma":[0.005885406,0.0002219329,0.09697391,0.0002241665,0.00008177203,0.00001841194,0.0004340252,0.000003436609,0.7982937,0.0003010634,0.09717271,0.0003894464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9534825,0.03038963,0.0001049379,0.004441442,0.0001579211,0.0005299857,0.0005076884,0.00006664739,0.01031924],"genre_scores_gemma":[0.9904805,0.007189857,0.0005760045,0.00002607938,0.000007631993,0.00003733341,0.0002688457,0.00001811959,0.001395576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1876604,"threshold_uncertainty_score":0.4962416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733269393510883,"score_gpt":0.2947163566402055,"score_spread":0.2673836627050966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}