{"id":"W2320063297","doi":"10.1515/hc.2000.6.3.199","title":"DESIGN AND SYNTHESIS OF A NEW CLASS OF PYRROLOBENZIMIDAZOLE BASED AGENTS TO TARGET HUMAN TUMOR HELICASES","year":2000,"lang":"en","type":"article","venue":"Heterocyclic Communications","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Class (philosophy); Chemistry; Helicase; Computational biology; Combinatorial chemistry; Computer science; Biochemistry; Artificial intelligence; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496045,0.0005095379,0.0004054331,0.0003866914,0.0002877915,0.000378707,0.0004324173,0.0003966396,0.001823863],"category_scores_gemma":[0.0001810272,0.0001862107,0.0002151803,0.0002245773,0.0002007265,0.0003015159,0.0001525964,0.00064018,0.0004417712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005493152,"about_ca_system_score_gemma":0.0006302026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001155038,"about_ca_topic_score_gemma":0.003307916,"domain_scores_codex":[0.9998637,0.00001595491,0.00001098108,0.00002472519,0.00004772482,0.00003689464],"domain_scores_gemma":[0.9999014,0.000009944212,0.00002045049,0.00000681327,0.00002280396,0.00003850377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000270637,0.0002801033,0.0001320756,0.0001978101,0.00001929425,0.0002368934,0.00009878153,0.00119204,0.9676485,0.001440341,0.0006366575,0.02784688],"study_design_scores_gemma":[0.0005336949,0.003754848,0.0008856242,0.00002260027,0.00006388725,0.0007757836,0.00002042411,0.002452427,0.9450953,0.0002234463,0.04614196,0.00003003035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8213831,0.02640234,0.1099066,0.0013541,0.0004649831,0.003587602,0.001474311,0.0007857197,0.03464116],"genre_scores_gemma":[0.9022062,0.01394312,0.06479378,0.0004776852,0.0001102671,0.0008332385,0.001563104,0.00005277926,0.01601977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001823863,"threshold_uncertainty_score":0.006101489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035943675835734,"score_gpt":0.3310790343621158,"score_spread":0.2274846667785424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}