{"id":"W2320114964","doi":"10.1021/cb200070k","title":"Phenylpyrrolocytosine as an Unobtrusive Base Modification for Monitoring Activity and Cellular Trafficking of siRNA","year":2011,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McGill University","funders":"","keywords":"Small interfering RNA; Gene silencing; Cytoplasm; Cell biology; Fluorescence microscope; Fluorescence; Biophysics; Chemistry; Biology; RNA; Gene; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002086536,0.0002575149,0.0001467449,0.0001117108,0.0001330388,0.0001930793,0.000190654,0.0003426954,0.0003648155],"category_scores_gemma":[0.0002042047,0.0001633125,0.0001091581,0.00008979272,0.0001602147,0.0001891014,0.0001701623,0.0003127115,0.0001414263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001720201,"about_ca_system_score_gemma":0.0001521756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003824612,"about_ca_topic_score_gemma":0.0006298249,"domain_scores_codex":[0.9998543,0.0000423293,0.000009426873,0.00003946721,0.00003804385,0.00001638841],"domain_scores_gemma":[0.9998846,0.00002832698,0.00003477333,0.00001882684,0.00001771494,0.00001565982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002173959,0.000003354291,0.0000407077,0.00001134539,0.000001101504,0.00002798992,0.000005986661,0.00004873937,0.999295,0.0000344386,0.000006377929,0.000503234],"study_design_scores_gemma":[0.000002388317,0.00007108684,0.0002956226,7.555674e-7,0.000002458391,0.0001033938,0.000002600864,0.0004443369,0.9987133,0.000005112579,0.0003571796,0.000001782996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982141,0.001054525,0.01524591,0.00006361154,0.00002060374,0.00004624692,0.0001122682,0.0001069921,0.001208818],"genre_scores_gemma":[0.9811295,0.0006875987,0.0169716,0.00002989851,0.000007118306,0.00003999119,0.0001192607,0.00001774319,0.0009973124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003824612,"threshold_uncertainty_score":0.001248062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04070837325478741,"score_gpt":0.2856526399191688,"score_spread":0.2449442666643814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}