{"id":"W2320114964","doi":"10.1021/cb200070k","title":"Phenylpyrrolocytosine as an Unobtrusive Base Modification for Monitoring Activity and Cellular Trafficking of siRNA","year":2011,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McGill University","funders":"","keywords":"Small interfering RNA; Gene silencing; Cytoplasm; Cell biology; Fluorescence microscope; Fluorescence; Biophysics; Chemistry; Biology; RNA; Gene; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009022156,0.0001208586,0.000158297,0.00002660277,0.00003101911,0.000003918357,0.0001451856,0.0002314588,0.000006094839],"category_scores_gemma":[0.00007952771,0.0001130777,0.0000495298,0.00003278361,0.0001299621,0.000007034962,0.00006243748,0.00006066313,0.000001253515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006692862,"about_ca_system_score_gemma":0.00002426485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005396889,"about_ca_topic_score_gemma":0.000002126747,"domain_scores_codex":[0.999276,0.00003072944,0.000152202,0.0003356024,0.00003014667,0.0001752536],"domain_scores_gemma":[0.9995032,0.00001982721,0.000093931,0.0002219433,0.00009814065,0.00006293865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004036041,0.0000866741,0.001700929,0.00001418779,0.00003312486,4.310982e-7,0.00009972107,0.000001040728,0.9905315,0.0000977907,0.000007129489,0.007023883],"study_design_scores_gemma":[0.000380929,0.0006331025,0.0005635096,0.000006693084,0.00002269778,0.000004220751,0.00005316561,0.00006940824,0.9976693,0.00037046,0.0001024169,0.000124091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980273,0.000234688,0.001362711,0.00002171371,0.00007488043,0.0001380378,0.00001987164,0.000008975317,0.0001118393],"genre_scores_gemma":[0.9985429,0.00009277202,0.001012516,0.00004238578,0.000156658,0.0000273492,0.0001004173,0.00001149218,0.00001350355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007137822,"threshold_uncertainty_score":0.4611174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04070837325478741,"score_gpt":0.2856526399191688,"score_spread":0.2449442666643814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}