{"id":"W2320121320","doi":"10.1093/annonc/mdw163","title":"Clinical outcomes with pemetrexed-based systemic therapies in RET-rearranged lung cancers","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Cancer Institute","keywords":"Medicine; KRAS; Pemetrexed; Discontinuation; ROS1; Internal medicine; Lung cancer; Oncology; Crizotinib; Retrospective cohort study; Anaplastic lymphoma kinase; Lung; Gene rearrangement; Gastroenterology; Adenocarcinoma; Cancer; Chemotherapy; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004458034,0.0001102771,0.0004490324,0.0001495238,0.0001482449,0.0004441356,0.0001471225,0.0002110832,0.001455379],"category_scores_gemma":[0.001641995,0.00004926557,0.0006831432,0.0002612349,0.0001541669,0.0005406016,0.0002304511,0.0006165022,0.0001572907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005407871,"about_ca_system_score_gemma":0.0002737668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007334516,"about_ca_topic_score_gemma":0.002152305,"domain_scores_codex":[0.9997371,0.00008471284,0.00003450908,0.00004959768,0.00004541657,0.00004863174],"domain_scores_gemma":[0.9993109,0.0002563256,0.0002184773,0.00002975095,0.00007083457,0.000113692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.03217202,0.001084329,0.4652974,0.001066677,0.002673399,0.0009634095,0.0002171964,0.004761856,0.00878882,0.0007341034,0.006240596,0.4760002],"study_design_scores_gemma":[0.00128277,0.01040439,0.9725221,0.0002936922,0.002207202,0.001624173,0.00031424,0.002303238,0.002057114,0.0008441286,0.006117913,0.00002892342],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97521,0.01625767,0.0003218992,0.0009976762,0.00008138568,0.00004543545,0.0008584944,0.00001408882,0.006213367],"genre_scores_gemma":[0.9953425,0.002502049,0.000115605,0.0002826419,0.0000734198,0.00002310226,0.0009417266,0.000004316249,0.0007146365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455379,"threshold_uncertainty_score":0.004868686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07948592838997814,"score_gpt":0.4737768886598802,"score_spread":0.394290960269902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}