{"id":"W2320136476","doi":"10.1097/00005344-200205000-00005","title":"Endothelin B Receptor-Mediated Regulation of Endothelin-1 Content and Release in Cultured Porcine Aorta Endothelial Cell","year":2002,"lang":"en","type":"article","venue":"Journal of Cardiovascular Pharmacology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; St. Michael's Hospital; Université de Montréal","funders":"","keywords":"Bosentan; Endothelin receptor; Endothelin 1; Internal medicine; Receptor; Endocrinology; Internalization; Endothelin receptor antagonist; Receptor antagonist; Endothelial stem cell; Antagonist; Biology; Chemistry; Medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001354233,0.0002733398,0.001344729,0.0005302136,0.00003463994,0.000007953502,0.0001421279,0.0002174444,0.0005608248],"category_scores_gemma":[0.0003428848,0.000219072,0.0008017523,0.0002896793,0.0001389081,0.0001481469,0.00003815618,0.0005776686,0.0000272142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001198726,"about_ca_system_score_gemma":0.00008437314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004571221,"about_ca_topic_score_gemma":0.000001347704,"domain_scores_codex":[0.9970996,0.0005178574,0.001128719,0.000273486,0.0006197014,0.0003605783],"domain_scores_gemma":[0.9981186,0.0003246687,0.0005651591,0.0002666551,0.0004444181,0.0002804571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001387509,0.0005039763,0.003323269,0.0002403227,0.001555608,0.0005591268,0.0003938849,0.0005146936,0.9818019,0.000008101726,0.00169149,0.008020148],"study_design_scores_gemma":[0.04404178,0.001521894,0.00293409,0.0002211814,0.002563211,0.002182474,0.0002657643,0.001611027,0.8897318,0.00003750258,0.05453952,0.0003497413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9574554,0.03886246,0.0003845124,0.0006414225,0.0008974274,0.0007211092,0.00005194677,0.00002212124,0.0009636254],"genre_scores_gemma":[0.9812391,0.01520577,0.001221986,0.0003854001,0.0009278541,0.00001248976,0.000008195887,0.00004417502,0.0009549856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09207005,"threshold_uncertainty_score":0.8933499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253875295737229,"score_gpt":0.2485830311487187,"score_spread":0.2260442781913464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}