{"id":"W2320193046","doi":"10.1093/neuonc/nou365","title":"Phase II study of PX-866 in recurrent glioblastoma","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"","keywords":"Medicine; Nausea; Internal medicine; Adverse effect; Gastroenterology; Vomiting; Clinical endpoint; Diarrhea; Phases of clinical research; Progression-free survival; Oncology; PTEN; Toxicity; Chemotherapy; PI3K/AKT/mTOR pathway; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00151956,0.001413148,0.001902161,0.0004760723,0.0003633229,0.000582895,0.0008363234,0.0009476154,0.003479469],"category_scores_gemma":[0.0005930798,0.0005001535,0.0008103209,0.0003750278,0.0005978166,0.0004346788,0.0004133908,0.002110216,0.0009339174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005792003,"about_ca_system_score_gemma":0.001506052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003228,"about_ca_topic_score_gemma":0.002282018,"domain_scores_codex":[0.9996031,0.0001786719,0.00002503556,0.00005658566,0.00005044249,0.00008624153],"domain_scores_gemma":[0.9995034,0.00004568916,0.0001071493,0.00004523194,0.00005755664,0.0002410904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5045141,0.1149103,0.0210457,0.002182945,0.002578177,0.0008231081,0.0007690386,0.004491878,0.1448273,0.0005703983,0.008225494,0.1950616],"study_design_scores_gemma":[0.2803673,0.6864274,0.01646795,0.00005237204,0.0006289751,0.0007389693,0.00009686908,0.001714457,0.00975187,0.0002137685,0.003506596,0.00003346968],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943405,0.001646769,0.0005974394,0.0002220505,0.00006979824,0.001876667,0.0005245077,0.00009795493,0.0006242426],"genre_scores_gemma":[0.989448,0.002087323,0.001556184,0.0004536894,0.00009049988,0.002288164,0.001856058,0.00002854358,0.002191642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003479469,"threshold_uncertainty_score":0.01164001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05185922930005898,"score_gpt":0.3693198056968334,"score_spread":0.3174605763967744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}