{"id":"W2320193046","doi":"10.1093/neuonc/nou365","title":"Phase II study of PX-866 in recurrent glioblastoma","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"","keywords":"Medicine; Nausea; Internal medicine; Adverse effect; Gastroenterology; Vomiting; Clinical endpoint; Diarrhea; Phases of clinical research; Progression-free survival; Oncology; PTEN; Toxicity; Chemotherapy; PI3K/AKT/mTOR pathway; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001913583,0.0001425406,0.0005137934,0.0002428994,0.00002523753,0.000002721747,0.00008119598,0.00008730673,0.00005210561],"category_scores_gemma":[0.0002405921,0.0001037184,0.00005530833,0.0002987207,0.00004592478,0.00003193474,0.0001017917,0.0001820901,0.00003186327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002135073,"about_ca_system_score_gemma":0.0001946561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007039124,"about_ca_topic_score_gemma":0.0005299296,"domain_scores_codex":[0.9986948,0.0001730657,0.0003823429,0.0002914142,0.0002288843,0.0002294516],"domain_scores_gemma":[0.9991093,0.0001537812,0.0001295206,0.0002972392,0.0001052758,0.0002049261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0110517,0.2956519,0.10998,0.00006025355,0.0002602128,0.01003485,0.01470475,0.00005177711,0.0924832,0.0001545794,0.03001215,0.4355546],"study_design_scores_gemma":[0.1463472,0.6103582,0.01289899,0.00007572032,0.0004683546,0.0003783255,0.004295593,0.0003237911,0.0452563,0.0001095559,0.1792193,0.0002686922],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995261,0.0001881516,5.764153e-7,0.001686386,0.0005419122,0.0008421296,0.000005455498,0.00002801223,0.001446415],"genre_scores_gemma":[0.9993942,0.00002373243,0.000040412,0.0002930261,0.00008470026,0.0001320788,0.000004897732,0.00001619921,0.00001072027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4352859,"threshold_uncertainty_score":0.4229512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05185922930005898,"score_gpt":0.3693198056968334,"score_spread":0.3174605763967744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}