{"id":"W2320282699","doi":"10.1021/ja106158b","title":"Postsynthetic Guanine Arylation of DNA by Suzuki−Miyaura Cross-Coupling","year":2010,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Oligonucleotide; Nucleobase; Guanine; Adduct; Circular dichroism; Electrospray ionization; DNA; Coupling reaction; Deoxyguanosine; Combinatorial chemistry; Stereochemistry; Nucleic acid; Mass spectrometry; Organic chemistry; Nucleotide; Biochemistry; Catalysis; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003893102,0.00112952,0.000394703,0.0004710253,0.000282136,0.0001933505,0.0004072261,0.0004817301,0.002530204],"category_scores_gemma":[0.0002978412,0.0004066273,0.0004165449,0.0003695679,0.0002503232,0.0002344539,0.0004214509,0.0009341158,0.001415723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003226967,"about_ca_system_score_gemma":0.0003675086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008996645,"about_ca_topic_score_gemma":0.002386105,"domain_scores_codex":[0.9996504,0.00006506858,0.0000270455,0.00009456107,0.00006625368,0.00009671881],"domain_scores_gemma":[0.9998379,0.00002581127,0.00003914494,0.00002655633,0.00004251779,0.00002803511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003332332,0.00002048201,0.00004839349,0.0001265583,0.00001285188,0.0001062267,0.00005371317,0.0001364889,0.995293,0.0002418789,0.0001009433,0.003826226],"study_design_scores_gemma":[0.00001674684,0.0004821726,0.0003855098,0.00000759766,0.00002177049,0.0001974106,0.0000149272,0.000341074,0.993373,0.00007708939,0.00506624,0.00001646745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8949733,0.005889456,0.08399801,0.0003390792,0.0003096115,0.0004854549,0.0006664371,0.001347008,0.01199164],"genre_scores_gemma":[0.9287089,0.004685338,0.05570998,0.0002327188,0.00004968882,0.0002995251,0.001071023,0.0001347311,0.00910809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002530204,"threshold_uncertainty_score":0.008464396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004404446484651965,"score_gpt":0.2741477635875113,"score_spread":0.2697433171028593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}