{"id":"W2320352679","doi":"10.1136/annrheumdis-2014-eular.1199","title":"THU0464 Lsd1-Mediated Demethylation of Histone H3 Lysine 9 Contributes to Interleukin 1-Induced Microsomal Prostaglandin E Synthase-1 Expression","year":2014,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Histone H3; Demethylase; Demethylation; Chromatin immunoprecipitation; Histone methylation; Molecular biology; Histone; Epigenetics; Regulation of gene expression; Gene expression; Biology; Chemistry; Biochemistry; DNA methylation; Promoter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002058499,0.0002801159,0.0003002142,0.0003209362,0.0004768776,0.0004764373,0.0002697151,0.0003255749,0.004103663],"category_scores_gemma":[0.0001850642,0.0002654653,0.0005286494,0.0001883598,0.0003530794,0.0002426485,0.0004094501,0.0006754178,0.001020245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000408953,"about_ca_system_score_gemma":0.0003691377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008066645,"about_ca_topic_score_gemma":0.001532849,"domain_scores_codex":[0.9998081,0.00002851981,0.00001361901,0.00004908129,0.00003187859,0.00006884179],"domain_scores_gemma":[0.9998536,0.00001280976,0.00004817333,0.00002171125,0.00002316596,0.00004057565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006735625,0.00005238486,0.001613117,0.00008060527,0.00002419914,0.000172902,0.00003402713,0.00006868061,0.9935348,0.0003188548,0.000317571,0.003109389],"study_design_scores_gemma":[0.00004524341,0.0002377266,0.02516179,0.00001288871,0.00003386088,0.0006626095,0.0001395087,0.001070363,0.9677377,0.0002496667,0.004636198,0.00001245254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870465,0.003956677,0.004089951,0.0004339381,0.0001913764,0.00003203571,0.0007895967,0.0002703366,0.003189689],"genre_scores_gemma":[0.9941106,0.0004118957,0.0008567173,0.00005564034,0.00001277819,0.00001395007,0.0006287131,0.00002035197,0.003889182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004103663,"threshold_uncertainty_score":0.01372814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191680634894225,"score_gpt":0.3250438620302303,"score_spread":0.3031270556812881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}